1701例儿童血清过敏原特异性IgE检测结果分析  

Analysis of serum allergen specific IgE in 1701 children in Shanghai

作　　者：陈雯 李玮泽 彭霞[1] CHEN Wen;LI Weize;PENG Xia(Department of Laboratory Medicine Center,the First People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院检验医学中心,上海200080

出　　处：《检验医学与临床》2024年第2期145-150,共6页Laboratory Medicine and Clinic

基　　金：国家自然科学基金项目(81971513)。

摘　　要：目的了解上海西南地区儿童过敏原过敏情况,为该地区儿童过敏性疾病的预防、诊断和治疗提供参考依据。方法选取2019年12月至2022年8月在该院就诊且疑患过敏的0~6岁1701例儿童作为研究对象。采用荧光酶免疫法检测血清过敏原总免疫球蛋白E(IgE)和特异性IgE(sIgE)抗体水平。分析血清过敏原sIgE分布情况,比较不同过敏原致敏的相关性。结果粉尘螨阳性率最高[49.2%(414/841)],其次依次为屋尘螨[48.6%(409/841)]、牛奶[43.5%(366/841)]、鸡蛋白[36.7%(309/841)]和混合真菌[16.4%(138/841)];男童上述过敏原阳性率均高于女童;吸入性过敏原阳性率随年龄增长而升高,食物过敏原致敏大多数发生在婴幼儿早期;吸入性过敏原血清sIgE水平高于食物过敏原。屋尘螨与粉尘螨、蟹和虾均呈正相关(P<0.05)。结论螨、牛奶、鸡蛋白是上海西南地区儿童的主要过敏原;男童比女童更易过敏;相似属性过敏原之间相关性更强,吸入性过敏原与食物过敏原也有关联。Objective To investigate the status of allergen allergy in children in the southwest area of Shanghai,and to provide reference for the prevention,diagnosis and treatment of allergic diseases in children in this area.Methods A total of 1701 children aged 0-6 years with suspected allergies who visited the hospital from December 2019 to August 2022 were selected as the research objects.Serum total immunoglobulin E(IgE)and specific IgE(sIgE)antibody levels were detected by fluorescent enzyme immunoassay.The distribution of serum allergen sIgE was analyzed,and the correlation of sensitization with different allergens was compared.Results The positive rate of dust mites was the highest[49.2%(414/841)],followed by household dust mites[48.6%(409/841)],milk[43.5%(366/841)],egg white[36.7%(309/841)]and mixed fungi[16.4%(138/841)].The positive rate of above allergens in boys were higher than those in girls.The positive rate of inhaled allergens increased with age,and food allergen sensitization mostly occurred in early infancy.The serum sIgE level of inhaled allergens was higher than that of food allergens.Household dust mites was a positive correlation with dust mites,crab and shrimp(P<0.05).Conclusion Mite,milk and egg white are the main allergens of children in southwest Shanghai.Boys were more susceptible to allergies than girls.The correlation between allergens with similar attributes is stronger,and inhaled allergens are also associated with food allergens.

关 键 词：儿童 过敏 特异性免疫球蛋白E 吸入性过敏原 食物过敏原 

分 类 号：R392[医药卫生—免疫学]