电磁场暴露中实验动物的热剂量学研究  

Thermal dose of experimental animals exposed in electromagnetic field

作　　者：林加金 李静 丁桂荣 LIN Jiajin;LI Jing;DING Guirong(Department of Radiation Biology,Faculty of Preventive Medicine,Air Force Medical University/Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,Xi'an 710032,China)

机构地区：[1]空军军医大学军事预防医学系辐射防护医学教研室/特殊作业环境危害评估与防治教育部重点实验室,陕西西安710032

出　　处：《中国医学物理学杂志》2024年第1期88-94,共7页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(31770905);军队后勤科研项目(BKJ19C019)。

摘　　要：本文开展了电磁暴露下实验动物的热剂量学特征研究。基于生物热方程和数字化三维大鼠模型建立了电磁剂量和热剂量仿真环境,评估了比吸收率、代谢率和边界条件对温度分布及变化的影响。结果表明:核心温升随全身平均比吸收率(WBASAR)增加而增加;在WBASAR值为4 W/kg的电磁波照射下,中脑和睾丸因趋肤效应具有较高的比吸收率值,导致器官组织的温升明显高于核心温升;在WBASAR值为0.4 W/kg的电磁波照射下,代谢和外界环境突变引起的浅层器官温度变化可达到1℃,远高于核心温升值。在实验评估中,头部和睾丸等靶器官是关键的热剂量评估对象;在实验设计中,需合理规范实验条件,降低代谢率和热边界条件对热剂量的影响。本研究为生物电磁学实验设计及效应研究提供热剂量学评估基础。The study explores the thermal dose of experimental animals exposed in electromagnetic field.The simulation environment containing electromagnetic and thermal doses is established based on the bioheat equation and the threedimensional rat model,and the effects of specific absorption rate,metabolic rate and boundary condition on temperature distribution and variation are assessed.The result shows that the core temperature rises with increasing whole body average specific absorption rate(WBASAR).At WBASAR of 4 W/kg,the midbrain and testes have higher specific absorption rates due to the skin effect,resulting in a more significant temperature rise in organ tissues than in the core;and atWBASAR of 0.4 W/kg,the temperature variation of the shallow organs caused by the sudden changes of metabolic and external environment reaches 1℃,which is much larger than that of the core.The experiment demonstrates target organs such as the head and testicles as critical subjects in thermal dose assessment.The experimental conditions should be regulated to reduce the effects of metabolic rate and boundary condition on thermal dose.The study has guiding significance for bioelectromagnetic experimental design and effect evaluation on thermal dose.

关 键 词：电磁场 传热学 剂量 温度 边界条件 

分 类 号：R318[医药卫生—生物医学工程] Q64[医药卫生—基础医学]