分子印迹传感器在兽药残留分析领域研究进展  

Research Progress of Molecular Imprinting Sensors in the Field of Veterinary Drug Residue Analysis

作　　者：玄艺 张宇 黄晓宁 姜昕妤 魏可欣 王晓通 谢晓程 李臣贵 XUAN Yi;ZHANG Yu;HUANG Xiaoning;JIANG Xinyu;WEI Kexin;WANG Xiaotong;XIE Xiaocheng;LI Chengui(School of Animal Science and Technology,Shandong Agricultural University,Tai’an 271000,China;Key Laboratory of Animal Biotechnology and Disease Control in Shandong Province,Tai’an 271000,China)

机构地区：[1]山东农业大学动物科技学院,泰安271000 [2]山东省动物生物工程与疾病防治重点实验室,泰安271000

出　　处：《中国畜牧兽医》2024年第1期427-433,共7页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金资助项目(31602111);中国博士后基金资助项目(2017M612314);山东省“双一流学科”项目。

摘　　要：动物源食品中兽药、微生物毒素、防腐剂以及食品加工过程中的药物残留可引起明显的毒性作用和过敏反应,给人类健康带来威胁。分子印迹技术主要通过诱导模板在聚合物中形成特定识别位点,具有预定性、识别性以及实用性等优点,在兽药残留检测领域发挥了重要作用。使用分子印迹技术制备的聚合物受体所具有的坚固性、高亲和力、特异性和生产成本低等特性,使它们成为天然受体以及有毒化合物可选择的替代品。将分子印迹技术与传感器技术相结合,使两者的优势特点充分发挥,聚合物科学和纳米技术的进步有助于提高分子印迹聚合物传感器的性能,分子印迹传感器所适用的领域也进一步扩大。近年来许多高质量文献报道了分子印迹聚合物传感器在生物分子、滥用药物和爆炸物等领域的研究,推动了该技术在生命科学和危化品领域的应用。作者重点简述了分子印迹技术与分子印迹传感器的原理,介绍了基于分子印迹聚合物的传感器技术的最新成就以及面向兽药残留检测应用领域的研究。Animal derived foods containing veterinary drugs,microbial toxins,preservatives,and drug residues during food processing can cause significant toxic effects and allergic reactions,posing a threat to human health.Molecular imprinting technology mainly induces templates to form specific recognition sites in polymers,which has advantages such as predictability,recognition,and practicality,and has played an important role in the field of veterinary drug residue detection.The robustness,high affinity,specificity,and low production cost of polymer receptors prepared using molecular imprinting technology make them an alternative to natural receptors and toxic compounds.By combining molecular imprinting technology with sensor technology,the advantages and characteristics of both can be fully utilized.The progress of polymer science and nanotechnology can help improve the performance of molecular imprinted polymer sensors,and the applicable fields of molecular imprinted sensors are further expanded.In recent years,many high-quality literature has reported on the research of molecularly imprinted polymer sensors in the fields of biomolecules,abused drugs,and explosives,promoting the application of this technology in the fields of life sciences and hazardous chemicals.The author focuses on the principles of molecular imprinting technology and molecular imprinting sensors,and introduces the latest achievements of sensor technology based on molecular imprinted polymers,as well as research in the field of veterinary drug residue detection applications.

关 键 词：分子印迹 分子印迹聚合物 分子印迹传感器 兽药残留 

分 类 号：S859.1[农业科学—临床兽医学]