比较TACE+微波消融+程序性死亡受体-1与TACE+微波消融治疗原发性肝癌  

Comparison on TACE+microwave ablation+programmed death-1 and TACE+microwave ablation for treating primary hepatic carcinoma

作　　者：董畅 李威[1] 满文玲 孙维玮 杨坡[1] DONG Chang;LI Wei;MAN Wenling;SUN Weiwei;YANG Po(Department of Interventional Vascular surgery,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院介入血管外科,黑龙江哈尔滨150001

出　　处：《中国介入影像与治疗学》2024年第1期7-11,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的比较TACE+微波消融(MWA)+程序性死亡受体-1(PD-1)与TACE+MWA治疗原发性肝癌(PHC)的价值。方法回顾性纳入接受TACE+MWA+PD-1(观察组)或TACE+MWA治疗(对照组)的PHC患者各40例,比较组间基线资料、疗效和并发症。结果2组患者基线资料差异均无统计学意义(P均>0.05)。观察组与对照组客观缓解率(ORR)分别为90.00%和72.50%,疾病控制率(DCR)分别为97.50%和95.00%;组间差异均无统计学意义(P均>0.05)。观察组与对照组中位总生存期(OS)分别为30.80个月和15.70个月,中位无进展生存期(PFS)分别为23.35个月和6.80个月;观察组OS和PFS均长于对照组(P均<0.05)。组间并发症发生率差异均无统计学意义(P均>0.05),且均经相关对症治疗后好转。结论TACE+MWA+PD-1联合治疗PHC效果优于TACE+MWA。Objective To compare the value of TACE+microwave ablation(MWA)+programmed death-1(PD-1)and TACE+MWA for treating primary hepatic carcinoma(PHC).Methods Data of 80 PHC patients who underwent TACE+MWA+PD-1(observe group)or TACE+MWA treatment(control group)were retrospectively analyzed(each n=40).The baseline data,therapeutic efficacy of PHC and complications were compared between groups.Results No significant difference of baseline data was found between groups(all P>0.05).The objective response rate(ORR)of observe group and control group was 90.00%and 72.50%,respectively,while the disease control rate(DCR)was 97.50%and 95.00%,respectively,with no significant difference between groups(both P>0.05).The median overall survival(OS)of observe group and control group was 30.80 months and 15.70 months,respectively,while the median progression free survival(PFS)was 23.35 months and 6.80 months,respectively.OS and PFS of observe group were both longer than those of control group(both P<0.05).No significant difference of the incidence of complications was detected between groups(all P>0.05),and all were improved after symptomatic treatment.Conclusion TACE+MWA+PD-1 was superior to TACE+MWA for treating PHC.

关 键 词：肝肿瘤 消融技术 化学栓塞 治疗性 程序性细胞死亡1受体 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]