PI3K/AKT/mTOR信号通路在多发性骨髓瘤中作用机制的研究进展  

Research Progress on the Mechanism of PI3K/AKT/mTOR Signaling Pathway in Multiple Myeloma——Review

作　　者：刘青青 李宜蔷 程纬民[2] LIU Qing-Qing;LI Yi-Qiang;CHENG Wei-Min(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,Guangxi Zhuang Autonomous Region,China;Deparment of Hematology,The First filiated Hospital of Guangri University of Chinese Medicine,Nanning 530023,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学研究生学院,广西南宁530001 [2]广西中医药大学第一附属医院血液内科,广西南宁530023

出　　处：《中国实验血液学杂志》2024年第1期292-296,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金地区科学基金项目(81960839)。

摘　　要：PI3K/AKT/mTOR信号通路在肿瘤的发生发展、转归预后中具有重要的意义,与多发性骨髓瘤(MM)的发病密切相关。PI3K/AKT/mTOR信号通路可通过多途径、多靶点参与调节MM,如调控MM细胞生存的肿瘤微环境,影响肿瘤发展、迁移,调控MM细胞增殖、凋亡、自噬。研究表明,PI3K/AKT/mTOR信号通路被抑制后,MM细胞的凋亡、自噬被激活,促进MM细胞的死亡,抑制MM细胞的转移及复发。因此,深入研究PI3K/AKT/mTOR信号通路在MM中的作用机制有助于阐明MM的发病机理及转归预后。PI3K/AKT/mTOR signaling pathway is of great significance in the development and prognosis of tumors,and is closely related to the pathogenesis of multiple myeloma(MM).PI3K/AKT/mTOR signaling pathway can participate in the regulation of MM through multi-channel and multi-target,such as regulating the tumor microenvironment of MM cells survival,affecting tumor development and migration,regulating the proliferation,apoptosis and autophagy of MM cells.It have shown that after the PI3K/AKT/mTOR signaling pathway is inhibited,the apoptosis and autophagy of MM cells are activated,which promote the death of MM cells and inhibit the metastasis and recurrence of MM cells.Therefore,in-depth study of the mechanism of PI3K/AKT/mTOR signaling pathway in MM is helpful to elucidate the pathogenesis and prognosis of MM.

关 键 词：PI3K/AKT/MTOR 多发性骨髓瘤 作用机制 

分 类 号：R733.3[医药卫生—肿瘤]