IL-6/IL-6R/JAK2/STAT3通路调控骨髓微环境对多发性骨髓瘤生物学行为影响的研究进展  

Research Progress on Effect of Bone Marrow Microenvironment Regulated by IL-6/IL-6R/JAK2/STAT3 Pathway on Biological Behavior of Multiple Myeloma——Review

作　　者：石玉士 许家威 刘青青 李宜蔷 程纬民[2] SHI Yu-Shi;XU Jia-Wei;LIU Qing-Qing;LI Yi-Qiang;CHENG Wei-Min(The First Clinical Medical College of Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China;Department of Hematology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学第一临床医学院,广西南宁530200 [2]广西中医药大学第一附属医院血液内科,广西南宁530023

出　　处：《中国实验血液学杂志》2024年第1期318-321,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金地区科学基金项目(81960839)。

摘　　要：多发性骨髓瘤(MM)是一种克隆浆细胞异常增殖的恶性疾病,疾病的发展表现出广泛的异质性,这种异质性与MM肿瘤细胞、骨髓微环境之间的相互作用密切相关。IL-6/IL-6R/JAK2/STAT3通路可以调节骨髓微环境中相关可溶性因子的转录,促进MM肿瘤细胞增殖、抗凋亡、产生耐药性及引导相关骨破坏。本文就IL-6/IL-6R/JAK2/STAT3通路调控骨髓微环境对MM生物学行为影响的研究进展进行综述,以期为MM的靶向治疗及精准治疗提供新的研究思路。Multiple myeloma(MM)is a malignant disease with abnormal proliferation of clonal plasma cells.The development of the disease shows a vast heterogeneity,which is closely related to the interaction between MM cells and bone marrow microenvironment(BMM).The interleukin-6(IL-6)/interleukin-6 receptor(IL-6R)/Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)pathway can regulate the transcription of related soluble factors in BMM,promote the proliferation,anti-apoptosis,drug resistance and guide related bone destruction of MM cells.This article reviews the research progress on the effect of BMM regulated by IL-6/IL-6R/JAK2/STAT3 pathway on the biological behavior of MM,in order to provide new research ideas for targeted therapy and precise therapy of MM.

关 键 词：多发性骨髓瘤 骨髓微环境 白介素-6/白介素-6受体 JANUS激酶2 信号转导和转录活化蛋白3 

分 类 号：R733.3[医药卫生—肿瘤]