基于Logistic回归模型和PCA模型的急性缺血性脑卒中发作影响因素分析  

Analysis of influencing factors of acute ischemic stroke attack based on Logistic regression model and PCA model

作　　者：沈惠文 陈淑良[1] 李桂茹[1] 马春野[1] 张立红[2] 马得原 张策[1] SHEN Huiwen;CHEN Shuliang;LI Guiru;MA Chunye;ZHANG Lihong;MA Deyuan;ZHANG Ce(the Second Hospital of Dalian Medical University,Dalian 116027;Dalian Municipal Central Hospital,Dalian 116027,China)

机构地区：[1]大连医科大学附属第二医院,辽宁大连116027 [2]大连市中心医院,辽宁大连116027

出　　处：《临床医学研究与实践》2024年第3期9-12,共4页Clinical Research and Practice

基　　金：北京市2021年康盟慈善基金会医学科研发展基金项目(No.B21036EN)。

摘　　要：目的应用Logistic回归模型和主成分分析(PCA)模型分析急性缺血性脑卒中(AIS)发作的影响因素。方法从大连医科大学附属第二医院医渡云科研大数据服务器系统提取2001年1月1日至2021年12月31日的数据,将医院病历系统收录的55620例AIS患者纳入病例组,将筛选后的64134例在医院体检中心体检的人群纳入对照组。收集两组的临床资料,分析AIS发作的影响因素。结果多因素分析结果显示,年龄、性别、肌酐、白细胞计数、血红蛋白、红细胞计数、血小板计数、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、丙氨酸氨基转移酶(ALT)、总胆固醇(TC)、γ-谷氨酰转移酶(γ-GGT)水平及吸烟史、饮酒史、高血压、糖尿病、心梗、冠心病、动脉粥样硬化为AIS的影响因素(P<0.05);受试者工作特征(ROC)曲线下面积(AUC)为0.927。PCA提取8个主成分,既往病史、血脂水平风险比较大。结论既往病史及血脂水平是AIS发作的主要影响因素,有效控制原发疾病及血脂水平能够更好控制AIS发作。Objective To analyze the influencing factors of acute ischemic stroke(AIS)attack by Logistic regression model and principal component analysis(PCA)model.Methods The data from January 1,2001 to December 31,2021 were extracted from the big data server system of Yiduyun scientific research in the Second Hospital of Dalian Medical University,55620 AIS patients included in the hospital medical record system were included in case group,and 64134 cases who underwent physical examination in the hospital physical examination center were included in control group.The clinical data of the two groups were collected,and the influencing factors of AIS attack were analyzed.Results Multivariate analysis results showed that age,gender,creatinine,white blood cell count,hemoglobin,red blood cell count,platelet count,triglyceride(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),alanine aminotransferase(ALT),total cholesterol(TC),γ-glutamyl transferase(γ-GGT)levels and smoking history,drinking history,hypertension,diabetes,myocardial infarction,coronary heart disease and atherosclerosis were the influencing factors of AIS(P<0.05);the area under the receiver operating characteristic(ROC)areas under curve(AUC)was 0.927.PCA extracted 8 principal components,with the higher odds radio of past medical history and blood lipid level.Conclusion Past medical history and blood lipid level are the main influencing factors of AIS attack.Effective control of primary disease and blood lipid level can better control the occurrence of AIS.

关 键 词：急性缺血性脑卒中 LOGISTIC回归模型 主成分分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]