错配修复蛋白3在口腔鳞状细胞癌中的表达及意义  

Expression of MutS homolog 3 in oral squamous cell carcinoma and its significance

作　　者：修小斐 高峰[1] 王晓梅[1] 徐嘉曼 肖雪兰 王大维[2] XIU Xiaofei;GAO Feng;WANG Xiaomei;XU Jiaman;XIAO Xuelan;WANG Dawei(Department of Pathology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,Hebei,China;Department of Oral surgery,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,Hebei,China)

机构地区：[1]河北医科大学第三医院病理科,河北石家庄050051 [2]河北医科大学第三医院口腔外科,河北石家庄050051

出　　处：《中国现代医生》2024年第2期26-28,共3页China Modern Doctor

基　　金：河北省财政厅资助临床医学优秀人才培养项目。

摘　　要：目的 探讨错配修复蛋白3(MutS homolog 3,MSH3)在口腔鳞状细胞癌中的表达及意义。方法 采用免疫组化检测20例正常口腔黏膜和60例口腔鳞状细胞癌组织中MSH3蛋白的表达。结果 口腔鳞状细胞癌组织中MSH3的阳性表达低于正常口腔黏膜。其中,高分化和中分化鳞状细胞癌中MSH3阳性表达高于低分化。与有淋巴结转移的鳞状细胞癌患者比较,无淋巴结转移的患者MSH3阳性表达明显升高。MSH3表达与患者性别、年龄、肿瘤部位、肿瘤大小无相关性。结论 MSH3蛋白表达降低与口腔鳞状细胞癌的分化程度和淋巴结转移相关,MSH3可能在口腔鳞状细胞癌进展过程中发挥重要作用。Objective To investigate the expression of MutS homolog 3 (MSH3) in oral squamous cell carcinoma and its significance. Methods The MSH3 protein expression was examined by immunohistochemistry in 20 normal oral mucosa and 60 oral squamous cell carcinoma tissues. Results Our results showed that MSH3 expression in oral squamous cell carcinoma tissues was lower than normal oral mucosa. The MSH3 expression in oral squamous cell carcinoma tissues with better differentiation was higher than that with worse differentiation. The positive MSH3 expression decreased from oral squamous cell carcinoma patients without lymph nodal metastasis to that with metastasis. MSH3 expression was not related to the patients’ gender, age, tumour location or size. Conclusion Downregulation of MSH3 is consistent with poorly differentiation and nodal metastasis in oral squamous cell carcinoma. MSH3 may play a significant role in the malignant progression of oral squamous cell carcinoma.

关 键 词：错配修复蛋白3 口腔鳞状细胞癌 免疫组化 分化程度 转移 

分 类 号：R739.8[医药卫生—肿瘤]