胆囊切除术后肠道微生态失衡的研究进展  

Research Progress in Intestinal Dysbiosis after Cholecystectomy

作　　者：李思宇 黄玉珍 刘万里 LI Siyu;HUANG Yuzhen;LIU Wanli(Graduate School,Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of Spleen and Stomach Diseases,Nanjing Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing 210014,China;Nanjing First Hospital,Nanjing 210006,China)

机构地区：[1]南京中医药大学研究生院,江苏南京210023 [2]南京市中西医结合医院脾胃病科,江苏南京210014 [3]南京市第一医院院部,江苏南京210006

出　　处：《基层中医药》2023年第12期142-148,共7页Basic Traditional Chinese Medicine

基　　金：2020年度南京市卫生科技发展专项资金项目(YKK20161)。

摘　　要：胆囊切除术后可能会引发肠道微生态失衡,从而诱发腹泻、消化不良、结直肠癌等消化系统疾病,影响患者生命健康。胆囊切除术后肠道微生态失衡的病理生理机制复杂,可能与医源性因素、胆汁酸与肠道菌群相互作用失调、肠道酸碱失衡、肠道免疫稳态失调、肠道黏膜屏障损伤等因素相关。本文通过查阅2017年至2023年中国知网(CNKI)、万方、维普、PubMed等数据库中的相关文献,在阐明可能引发胆囊切除术后肠道微生态失衡机制的基础上,进一步分析了中医病机特点,并对现有治疗策略如中药、针刺、艾灸等进行阐述,旨在为临床治疗因胆囊切除术后诱发的相关疾病提供新的思路。Cholecystectomy may lead to an imbalance in the intestinal microecology,which can cause digestive system diseases such as diarrhea,indigestion,and colorectal cancer,affecting the life and health of patients.The pathophysiological mechanism of intestinal dysbiosis after cholecystectomy is complex,which may be related to iatrogenic factors,imbalanced interaction between bile acids and intestinal flora,intestinal acid-base imbalance,intestinal immune dyshomeostasis,intestinal mucosal barrier damage and other factors.The article reviews relevant articles in databases such as the China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,and Pub Med from 2017 to 2023.After elucidating the mechanism of intestinal dysbiosis after cholecystectomy,this paper analyzes the traditional Chinese medicine(TCM) pathogenesis of this condition and elaborates on the available therapies such as Chinese medicines,acupuncture,and moxibustion,aiming to provide new ideas for clinical treatment of the diseases induced by cholecystectomy.

关 键 词：胆囊切除术后 肠道微生态失衡 发病机制 中医病机特点 中医治疗 

分 类 号：R73[医药卫生—肿瘤]