Jianpi Qutan Fang(健脾祛痰方)induces anti-atherosclerosis and ameliorates endothelial cell injury in high-fat diet rats via an anti-inflammatory and inhibiting Janus kinase/signal transducer and activator of transcription signaling pathway  

作　　者：LIU Yue ZHANG Fan HAN Xiaomeng XU Ningyang ZHAO Yu WANG Qige WANG Jianan LU Bingjiu Zhang Yan 

机构地区：[1]Studio of Prestigious Chinese physician Zhang Yan,Affiliated hospital,Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China [2]Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China [3]Department of Infectious Disease,Affiliated hospital,Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China [4]Studio of Prestigious Chinese physician Zhang Yan,Department of Cardiopulmonary Rehabilitation,Affiliated hospital,Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第6期1168-1175,共8页中医杂志（英文版）

基　　金：the National Natural Science Foundation of China:Explore the Regulatory Mechanism of Coronary Endothelial Immune Inflammation Mediated by Micro RNA155-SOCS1 Axis in Bama Pigs based on “Xin Shou Qi Yu Pi”(No.81703970);the National 973 Program on Key Basic Research Project:Study on the Therapeutic Mechanism and Rule of Treating Angina Pectoris based on “Cong Pi Lun Zhi”(No.2013CB531704)

摘　　要：OBJECTIVE:To investiage the possible mechanism underlying the effect of the Jianpi Qutan Fang(健脾祛痰方,JPQT)on Atherosclerosis(AS)which is the main pathological process of most cardiovascular diseases that affect millions of adults worldwide.METHODS:In the present study,rats were fed with a high-fat-diet(HFD)with vitamin D3 for 16 weeks and were orally administered atorvastatin treatment and different doses of JPQT.Histopathological changes and ultrastructural changes in the aorta were evaluated through hematoxylin-eosin staining and transmission electron microscopy(TEM),respectively.Suppressor of cytokine signaling 1(SOCS1)/Janus kinase 1(JAK1)/signal transducer and activator of transcription 1(STAT1)signaling pathways were detected through Western blotting.RESULTS:JPQT treatment decreased the lipid levels of triglyceride,low-density lipoprotein,and cholesterol,the inflammatory cytokine levels of interleukin 1 beta(IL-1β),IL-6 and IL-8 in rat serum,but increased high-density lipoprotein and IL-10 serum levels.JPQT treatment ameliorated pathological changes in the aorta of AS model rats.Moreover,JPQT upregulated SOCS1 protein expression and down-regulated phosphorylated protein expression levels of p-JAK1 and p-STAT1.CONCLUSION:These results suggest that JPQT induces anti-atherosclerosis effects through anti-inflammatory and inhibiting JAK/STAT signaling pathways in HFD fed rats.

关 键 词：anti-inflammatory agents Janus kinases STAT transcription factors signal transduction DIET HIGH-FAT antiatherosclerosis Jianpi Qutan Fang 

分 类 号：R285.5[医药卫生—中药学]