基于病因学理论探讨肠道菌群失调之六淫属性  

Exploring the characteristics of six climatic exopathogens causing intestinal flora dysregulation based on etiological theory

作　　者：王俞铧 梁笑妍 陈昊昱 任雪童 杨天笑 刘少伟 王彦刚 WANG Yuhua;LIANG Xiaoyan;CHEN Haoyu;REN Xuetong;YANG Tianxiao;LIU Shaowei;WANG Yangang(The First Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China;The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine,Foshan 510006,China;Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)

机构地区：[1]河北中医药大学第一附属医院,石家庄050091 [2]广州中医药大学第八临床医学院 [3]北京中医药大学第三附属医院

出　　处：《北京中医药大学学报》2023年第12期1658-1664,共7页Journal of Beijing University of Traditional Chinese Medicine

基　　金：河北省自然科学基金资助项目(No.H2020423207);北京市自然科学基金资助项目(No.7232281);河北省中医药管理局科研计划项目(No.2024097,No.2024012)。

摘　　要：肠道菌群与疾病之间的关系是目前的研究热点,但多倾向于对其因果关系及发病机制的阐述,尚缺乏病因学视角下肠道微生态紊乱的中医特色探讨,混杂菌群的中医致病特点亟待进一步厘清。肠道菌群是机体内部与外界环境沟通的重要桥梁,在疾病的诊断、预后、治疗中扮演重要且复杂的角色。本文基于中医病因学理论,从肠道微生态紊乱的基本概念、形成原因、致病性质与特点等方面,结合神经系统、免疫系统、腺体分泌及营养代谢理论,以临床表现为依据,运用审症求因的方法,探讨肠道微生态紊乱导致风、火、燥、湿、寒变化的科学内涵。希望本文能为肠道菌群的中医学研究提供新的思路,补充、丰富病因学说内容,同时为肠道微生态紊乱可以促进各种复杂疾病的发生、发展的理解与研究提供新的理论依据。The relationship between intestinal flora and diseases is currently a hot topic of research,but most studies tend to explain causality and pathogenesis,and there is still a lack of studies of the traditional Chinese medicine(TCM)characteristics of intestinal microecological disorders from the perspective of etiology.The TCM pathogenic characteristics of hybrid flora need to be further clarified.The intestinal flora is an important bridge between the internal and the external environment of body,and plays an important and complex role in the diagnosis,prognosis,and treatment of diseases.Based on the etiology theory of TCM,this paper discusses the scientific connotation of changes of wind,fire,dryness,dampness,and cold caused by intestinal microecological disorder from the aspects of basic concepts,formation causes,and pathogenic nature and characteristics,combined with the nervous system,immune system,gland secretion,and nutritional metabolism,based on clinical manifestations,using the method of examining symptoms and seeking causes.This paper provides a new idea for the study of intestinal flora in TCM,and supplements and enriches the theory of etiology.At the same time,it provides an innovative theoretical basis for the understanding and research that intestinal microecological disorders can promote the occurrence and development of various complex diseases.

关 键 词：肠道菌群 肠道微生态紊乱 菌群失调 病因学说 

分 类 号：R223[医药卫生—中医基础理论]