《抗肿瘤坏死因子-α单克隆抗体治疗非感染性葡萄膜炎中国专家共识》解读  

Interpretation of the Chinese expert consensus on treatment of non-infectious uveitis with anti-tumor necrosis factor-alpha monoclonal antibody

作　　者：王茜子 郑文洁 张晓敏 Wang Xizi;Zheng Wenjie;Zhang Xiaomin(Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China;Department of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]天津医科大学眼科医院、眼视光学院、眼科研究所、国家眼耳鼻喉疾病临床医学研究中心、天津市分中心、天津市视网膜功能与疾病重点实验室,天津300384 [2]中国医学科学院、北京协和医学院、北京协和医院风湿免疫科,北京100730

出　　处：《中华眼底病杂志》2024年第1期20-26,共7页Chinese Journal of Ocular Fundus Diseases

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-037A)。

摘　　要：生物制剂作为继传统糖皮质激素及免疫调节药物后的新型治疗选择,因其具有较好的疗效和安全性,已广泛应用于非感染性葡萄膜炎的临床治疗。其中抗肿瘤坏死因子-α(TNF-α)单克隆抗体(以下简称为单抗)最为常用,但其在临床中的规范合理应用仍缺乏指导。海峡两岸医药卫生交流协会风湿免疫分会眼免疫学组牵头制定了《抗肿瘤坏死因子-α单克隆抗体治疗非感染性葡萄膜炎中国专家共识》,遵循共识制订原则,基于循证基础,结合多位专家的临床治疗经验,系统全面地对于阿达木单抗及英夫利昔单抗的应用进行推荐,形成12条应用建议。针对该共识要点进行解读,有助于提高眼科及风湿免疫科医师对抗TNF-α单抗的规范性和有效性应用。As a new treatment option after conventional corticosteroids and immunomodulatory drugs,biologics have been widely used in the clinical management of non-infectious uveitis in many countries due to their approved efficacy and safety.Anti-tumor necrosis factor-alpha monoclonal antibody is the most commonly used one.However,the guidance on its standardized application is lacking.The Ocular Immunology Group of Immunology and Rheumatology Academy in Cross-Straits Medicine Exchange Association compiled the Chinese expert consensus on treatment of non-infectious uveitis with anti-tumor necrosis factor-alpha monoclonal antibody.This evidence-based consensus is made according to the principle of consensus building and combines the clinical experience of the experts.Twelve recommendations are formatted on the application of Adalimumab and Infliximab.The interpretation of this consensus point will help improve the normative and effective application of anti-tumor necrosis factor-alpha monoclonal antibody in ophthalmologists,rheumatologists and immunologists.

关 键 词：抗肿瘤坏死因子-Α单克隆抗体 非感染性葡萄膜炎 专家共识 解读 

分 类 号：R773.9[医药卫生—眼科]