癫痫持续状态导致大脑损伤机制及治疗靶点的研究进展  

Research progress on the mechanism and therapeutic targets of brain injury caused by status epilepticus

作　　者：姜英楠 郭佳 孔庆霞[2] 黄书然[3] JIANG Yingnan;GUO Jia;KONG Qingxia;HUANG Shuran(Clinical Medical College of Jining Medical University,Jining 272000,China;Department of Neurology,Affiliated Hospital of Jining Medical University,Jining 272000,China;Department of Critical Care Medicine,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院临床医学院,济宁272000 [2]济宁医学院附属医院神经内科,济宁272000 [3]济宁医学院附属医院重症医学科,济宁272000

出　　处：《癫痫杂志》2024年第1期83-87,共5页Journal of Epilepsy

基　　金：济宁市重点研发计划项目(2022YXNS044)。

摘　　要：癫痫是最常见的神经系统疾病之一,癫痫持续状态(Status epilepticus,SE)则可造成中枢神经系统永久性神经元脑损伤,但是其损伤机制尚未完全阐明,解决这一问题将有助于寻找更多SE治疗靶点,使数千万癫痫病人获益。SE导致大脑神经元损伤的途径在神经炎症、细胞自噬、凋亡和焦亡、胶质细胞的增生和类别转化、大脑内神经递质的变化等方面有新进展,这将有益于发现治疗SE的新靶点,从而为研发新型抗癫痫发作药物奠定了基础。Epilepsy is one of the most common neurological disorders,and status epilepticus(SE)can lead to permanent neuronal brain damage in the central nervous system,but the mechanism is not clear.Solving this problem will help to find more SE therapeutic targets,benefiting tens of millions of epilepsy patients.The pathway of SE leading to neuronal damage in the brain has made new progress in neuroinflammation,autophagy,apoptosis and pyroptosis,glial cell hyperplasia and category transformation,and changes in neurotransmitters in the brain,which will be beneficial to the discovery of new targets for the treatment of SE,thus laying a foundation for the development of new anti-epileptic drugs.

关 键 词：癫痫持续状态 大脑损伤 治疗靶点 神经炎症 细胞自噬 

分 类 号：R742.1[医药卫生—神经病学与精神病学]