急性未分化白血病2例临床分析并文献复习  

Clinical analysis of two cases with acute undifferentiated leukemia and literature review

作　　者：徐腾飞[1] 高胜海[1] 刘金立 王晓毅[2] Xu Tengfei;Gao Shenghai;Liu Jinli;Wang Xiaoyi(Clinical Laboratory,Weihai Municipal Hospital,Weihai 264200,Shandong Province,China)

机构地区：[1]威海市立医院检验科,威海264200 [2]威海市立医院血液科,威海264200

出　　处：《国际输血及血液学杂志》2023年第5期419-427,共9页International Journal of Blood Transfusion and Hematology

摘　　要：目的探讨急性未分化白血病(AUL)的临床特点、诊断与治疗方法,并进行相关文献复习。方法选择2020年8月24日、2021年7月20日威海市立医院收治的2例AUL患者为研究对象。根据2例患者入院时间,将其依次编号为患者1、2。患者1~2均为男性,年龄分别为62、76岁。采用回顾性分析方法,收集其临床病例资料,包括临床特征及外周血常规、生化、凝血、骨髓细胞形态学、骨髓细胞免疫分型检查结果,诊断、治疗及预后。根据患者1~2临床症状及实验室检查结果,对其进行诊断及治疗。对患者1~2的随访分别截至2020年10月31日与2021年9月30日。本研究以"急性未分化白血病""系列不明急性白血病""急性髓细胞白血病""急性髓细胞白血病微分化型""acute undifferentiated leukemia""acute leukemia of ambiguous lineage""acute myeloid leukemia""acute myeloid leukemia with minimal differentiation""AUL""ALAL""AML"为中、英文关键词,检索中国知网数据库、万方数据知识服务平台和PubMed数据库中AUL相关文献,总结与本研究患者1~2相关的诊疗资料。文献检索时间为上述数据库建库至2022年8月30日。本研究获得威海市立医院伦理委员会审批(批准文号:2023042),并与患者签署临床研究知情同意书。结果①患者1因"乏力2个月,发热2 d,伴胸闷、憋气1 d"入本院治疗,患者1既往有"2型糖尿病"病史;曾于当地医院就诊,疗效不佳,遂转入本院进一步治疗。患者2因"发现颈部右侧肿物10+d"入本院治疗,同时右侧颈部疼痛,转颈吞咽时加重,伴发热,偶有胸闷、憋气,伴咳嗽;无其他疾病史和家族史。②入院后,患者1相关检查结果示,白细胞计数(WBC)为108.34×10^(9)/L,红细胞计数为2.86×10^(12)/L,血红蛋白(Hb)值为92 g/L,血小板计数为7×10^(9)/L;B型钠尿肽前体、降钙素原、C反应蛋白水平进行性升高;骨髓细胞形态学检查结果示,原始细胞比例为97.00%;骨髓细胞免疫分型�Objective To investigate the clinical features,diagnosis and treatment of acute undifferentiated leukemia(AUL),and review relevant literature.Methods On August 24,2020 and July 20,2021,2 patients with AUL admitted to Weihai Municipal Hospital were selected as study subjects,and numbered as patient 1 and 2 according to the time of admission.These 2 male patients were aged 62 and 76 years,respectively.A retrospective study was conducted to collect clinical data of 2 patients,including clinical features,peripheral blood routine examination,biochemical and coagulation examination,bone marrow cell morphology examination,bone marrow immune typing examination,diagnosis,treatment and prognosis.According to the clinical symptoms and laboratory results,the patients were diagnosed and treated.Patient 1 and 2 in the study were followed up until October 31,2020 and September 30,2021,respectively.China National Knowledge Infrastructure database,Wanfang Data Knowledge Service platform and PubMed database were searched using"acute undifferentiated leukemia""acute leukemia of ambiguous lineage""acute myeloid leukemia""acute myeloid leukemia with minimal differentiation""AUL""ALAL"and"AML"as keywords in Chinese and English.Related literature were summarized and reviewed.Literature search period was from the establishment of the database to August 30,2022.This study was approved by the Ethics Committee of Weihai Municipal Hospital(Approval No.2023042)and clinical research informed consent was signed with the patients.Results①Patient 1 was admitted due to"fatigue for 2 months,fever for 2 d,and chest tightness and suffocation for 1 d".Patient 1 had a history of type 2 diabetes.He was treated in a local hospital,but the effect was not well,so he was transferred to our hospital for further treatment.Patient 2 was admitted due to"the tumor which was found on the right side of the neck for 10+d",which was aggravated when the neck was swallowed,accompanied by fever,occasional chest tightness,suffrage and cough.②After admission,related

关 键 词：白血病 髓样 急性 诊断 药物疗法 联合 急性未分化白血病 系列不明急性白血病 急性髓细胞白血病微分化型 合并症 

分 类 号：R733.71[医药卫生—肿瘤]