子宫内膜癌组织中L1CAM表达与临床病理特征、ER、PR关系及其评估预后的价值  

Relationship between L1CAM expression and clinicopathological features,ER,PR in endometrial carcinoma and its prognostic value

作　　者：朱伟 王国庆[2] 施启丰 陈璐 王昊珏 ZHU Wei;WANG Guoqing;SHI Qifeng;CHEN Lu;WANG Haojue(Department of Pathology,Xishan People's Hospital Of Wuxi City,Wuxi Jiangsu 214105,China;Department of Pathology,Zhongda Hospital Southeast University,Wuxi Jiangsu 214105,China;Department of gynaecology and Obstetrics,Xishan People's Hospital Of Wuxi City,Nanjing Jiangsu 210009,China)

机构地区：[1]无锡市锡山人民医院病理科,江苏无锡214105 [2]东南大学附属中大医院病理科,江苏无锡214105 [3]无锡市锡山人民医院妇产科,江苏南京210009

出　　处：《中国妇产科临床杂志》2024年第1期34-37,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：江苏省妇幼健康科研课题(F201923);无锡市卫健委中青年拔尖人才资助计划(bj2020111)。

摘　　要：目的 探究子宫内膜癌组织中L1细胞黏附分子(L1CAM)的表达水平与临床病理特征、雌激素受体(ER)、孕激素受体(PR)的关系及其评估预后的价值。方法 选取无锡市锡山人民医院及东南大学附属中大医院2018年3月至2019年11月收治的子宫内膜癌患者47例,检测并比较其癌组织与癌旁组织中L1CAM、ER、PR的表达情况,分析癌组织L1CAM表达与临床病理特征、ER、PR关系。分析L1CAM表达对预后的评估价值。结果 与癌旁组织相比,癌组织L1CAM阳性表达更高,ER、PR阳性表达更低(P <0.05);L1CAM与ER、PR呈负相关性(r=-0.298、-0.556,P=0.003、0.000);Logistic回归分析显示组织分化、淋巴结转移、肌层浸润、ER、PR是影响癌组织中L1CAM阳性表达的影响因素(P <0.05);L1CAM评估生存预后价值较高,曲线下面积为0.697;Kaplan-Meier Plotter数据库发现低表达L1CAM的患者生存率较高。结论 L1CAM在子宫内膜癌组织中有异常高表达,且与ER、PR呈负相关性;L1CAM阳性表达可对组织分化、淋巴结转移及肌层浸润情况、ER、PR产生影响,对患者预后评估有一定的价值。Objective To investigate the relationship between the expression level of L1 cell adhesion molecule(L1CAM) and clinicopathological features,estrogen receptor(ER),progesterone receptor(PR) in endometrial carcinoma and its prognostic value.Methods A total of 47 patients with endometrial cancer were selected from Wuxi Xishan People's Hospital and Zhongda Hospital Affiliated to Southeast University from March 2018 to November 2019.The expression of L1CAM,ER and PR in cancer tissues and adjacent tissues were detected and compared,and the relationship between L1CAM expression and clinicopathological features,ER and PR in cancer tissues was analyzed.The prognostic value of L1CAM expression was also examined.Results The positive expression of L1CAM in cancer tissues was significantly higher than that in adjacent tissues,while the positive expression of ER and PR was significantly lower than that in adjacent tissues,with statistical significance(P <0.05).L1CAM was negatively correlated with ER and PR(r =-0.298,-0.556,P = 0.003,0.000).Logistic regression analysis showed that histological differentiation,lymph node metastasis,myometrial infiltration,ER and PR were the influencing factors on the positive expression of L1CAM in cancer tissues(P < 0.05).L1CAM had a higher survival prognostic value,and the area under the curve was 0.697.Kaplan-Meier Plotter revealed that patients with low expression of L1CAM had higher survival rate.Conclusions L1CAM has abnormally high expression in endometrial carcinoma tissues,and is negatively correlated with ER and PR.The degree of histological differentiation,lymph node metastasis and myometrial infiltration,ER and PR expression were the influencing factors of L1CAM positive expression,and L1CAM had a certain value in evaluating the survival and prognosis of patients.

关 键 词：子宫内膜癌 L1CAM 临床病理特征 雌激素受体 孕激素受体 

分 类 号：R737.33[医药卫生—肿瘤]