慢性内脏痛及诱发负性情绪的神经回路研究进展  

Research progress on neural circuits of negative emotions induced by chronic visceral pain

作　　者：常晓丽 张海燕[2] 张丽丽[2] 陈少宗[2] CHANG Xiaoli;ZHANG Haiyan;ZHANG Lili;CHEN Shaozong(College of Acupuncture and moxibustion,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Research Institute of Acupuncture and Moxibustion,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学针灸推拿学院,济南250355 [2]山东中医药大学针灸研究院,济南250355

出　　处：《中国疼痛医学杂志》2024年第1期57-62,共6页Chinese Journal of Pain Medicine

基　　金：山东省自然科学基金项目(ZR2023QH041);国家自然科学基金项目(82205290,82374572);国家重点研发计划项目(2022YFC3500602);山东省自然科学基金重大基础专项(ZR2020ZD17)。

摘　　要：慢性内脏痛及其诱发的负性情绪严重影响了病人的生活质量,并产生巨大的社会经济负担。然而,与其相关的神经回路和机制仍是尚未解决的生命科学难题。前扣带回和杏仁核是处理啮齿类动物和人类慢性疼痛感觉和情绪成分的核心脑区,因此,本文以慢性内脏痛中功能性胃肠疾病(肠易激综合征)为例,重点围绕上述核团,从神经回路水平,总结并分析肠易激综合征啮齿类动物模型内脏痛及诱发负性情绪脑回路的最新发现。同时还讨论了今后该研究领域相关的重要研究方向,为揭示慢性内脏痛及诱发负性情绪的机制研究提供新线索。Chronic visceral pain and its induced negative emotions reduce the quality of life of sufferers and have large socioeconomic costs.However,the neural circuits and mechanisms associated with it remain unsolved challenges in life sciences.Anterior cingulate cortex and amygdala are the core brain regions responsible for processing chronic pain sensation and emotional components in rodents and humans.Therefore,taking functional gastrointestinal diseases irritable bowel syndrome(IBS)in chronic visceral pain as an example,we focused on these brain regions to highlight the current progress in the neural circuits of negative emotions induced by visceral pain in rodent models of irritable bowel syndrome.In this process,we also discussed important research directions related to this field in the future,providing new clues for revealing the mechanisms of chronic visceral pain and inducing negative emotions.

关 键 词：慢性内脏痛 负性情绪 前扣带回 杏仁核 

分 类 号：R57[医药卫生—消化系统]