甲基斑蝥胺联合肝动脉化疗栓塞术治疗肝细胞肝癌的临床研究  

Clinical study of Methylcantharidmide combined with transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma

作　　者：丁逸文 徐新建 任冬青[1] 包凯沪[1] 黄祥忠[1] DING Yi-wen;XU Xin-jian;REN Dongqing;HUANG Xiang-zhong(Department of Interventional Radiology,Jiangyin Hospital Affiliated to Medical College of Southeast University,Jiangyin,Jiangsu,214400,China)

机构地区：[1]东南大学医学院附属江阴市人民医院介入科,江苏江阴214400

出　　处：《中西医结合肝病杂志》2024年第1期49-51,55,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：无锡市科技发展医疗卫生指导性计划项目(锡科社[2020]259号)。

摘　　要：目的:探讨甲基斑蝥胺联合肝动脉化疗栓塞术(TACE)治疗肝细胞肝癌的临床效果。方法:共纳入60例肝癌患者,其中试验组患者(甲基斑蝥胺联合TACE)30例,对照组患者(单纯TACE)30例。随访1年,评估谷氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、Child-Pugh评分、腹水分级、生存质量评分及肿瘤治疗反应。结果:试验组患者治疗12个月后谷氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素、Child-Pugh评分、腹水分级及生存质量评分较对照组有改善,差异有统计学意义(P<0.05);试验组患者12个月后客观缓解率与对照组差异无统计学意义(P>0.05),但12个月疾病控制率及生存率优于对照组(P<0.05)。结论:甲基斑蝥胺联合TACE治疗肝细胞肝癌,不仅能减轻肝功能损伤,改善患者生活质量,且能巩固TACE治疗效果,提高肿瘤疾病控制率及延长患者生存期。Objective:To investigate the clinical efficacy of Methylcantharidmide combined with transcatheter arterial chemoembolization(TACE)in treating hepatocellular carcinoma(HCC).Methods:A total of 60 HCC patients were included in the study,30 patients in the test group(combined with TACE)and 30 in the control group(TACE alone).After 12 months follow-up,glutamic-pyruvic transaminase(ALT),glutamic-oxalacetic transaminase(AST),total bilirubin(TBil),Child-Pugh(CP)score,ascites grade,quality of life(QOL),and tumor treatment response were evaluated.Results:After 12 months of treatment,ALT,AST,TBIL,CP score,ascites grade,and QOL score in the test group were statistically significant compared with the control group(P<0.05).There was no significant difference in the objective response rate between the two groups(P>0.05),while the disease control rate and survival rate of the test group were better than those of the control group(P<0.05).Conclusion:The treatment of Methylcantharidmide combined with TACE for HCC can not only reduce liver function damage,and improve the quality of life of patients,but also consolidate the treatment efficacy of TACE,improve the control rate of tumor and prolong the survival of patients,which is worthy of further clinical research and application.

关 键 词：肝细胞肝癌 甲基斑蝥胺 肝动脉化疗栓塞术 

分 类 号：R739.5[医药卫生—肿瘤]