矢车菊素半合成方法实验教学实践  

Comprehensive Experiments in Organic Chemistry:A Semi-Synthetic Method for Cyanidin

作　　者：侯婷婷 刘渝钶 杨胜男 孙萌萌 胡海鹏 王广途 王晗光 吴贺君 蒲祥 Hou Tingting;Liu Yuke;Yang Shengnan;Sun Mengmeng;Hu Haipeng;Wang Guangtu;Wang Hanguang;Wu Hejun;Pu Xiang(College of Science,Sichuan Agricultural University,Ya an 625014,China)

机构地区：[1]四川农业大学理学院,四川雅安625014

出　　处：《云南化工》2024年第1期30-33,37,共5页Yunnan Chemical Technology

基　　金：四川省教育厅教改项目(JG2018-352,JG2021-484);四川农业大学双带头人教师党支部书记工作室(蒲祥);四川农业大学教改项目(X201935,X202138)。

摘　　要：使用槲皮素为原料,在室温条件下采用羟基保护、羰基还原和酸化成盐脱保护三步反应合成了天然活性成分矢车菊素。使用薄层色谱、紫外、液质联用和红外光谱技术来监测反应和表征产物。实验原理简单,操作简便,底物与产物最大吸收波长差异大。实验过程颜色变化明显,实验总产率为51.74%。矢车菊素应用广泛,通过合成实验可有效引导学生将有机化学基本理论学以致用,激发学生学习兴趣和提高实验技能。In this experiment,quercetin was used as the starting substrate to synthesize cyanidin,a natural active ingredient,under room temperature through hydroxyl groups protection,carbonyl reduction,and deprotection by acidification.The intermediate and final product were characterized by TLC,UV,HPLC-MS,and IR.The experimental principle is simple and the operation is convenient for college students.The maximum absorption wavelength of the substrate and product are significantly different.The color change is obvious,and the final yield is 51.74%.Cyanidin is widely used in food industry.Therefore,the preparation of cyanidin through synthetic method can effectively guide students to apply organic chemistry theory into practice,stimulate students interest,and improve experimental skills.

关 键 词：有机化学实验 羟基保护 酸化脱保护 矢车菊素 综合实验 

分 类 号：G633[文化科学—教育学]