外泌体在缺血性卒中诊断及治疗中的研究与应用  

Research and application of exosomes in the diagnosis and treatment of ischemic stroke

作　　者：尹文婧 曲瑒 任佳欣 马虹印(综述) 郭珍妮[1] 杨弋(审校)[1] YIN Wenjing;QU Yang;REN Jiaxin(Stroke Center,The Neurology Hospital,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院神经专科医院卒中中心,吉林长春130021

出　　处：《中风与神经疾病杂志》2024年第1期3-6,F0002,共5页Journal of Apoplexy and Nervous Diseases

基　　金：吉林大学白求恩医学部(2022JBGS03);吉林省科技厅(YDZJ202302CXJD061、20220303002SF);吉林省重点实验室(YDZJ202302CXJD017)。

摘　　要：缺血性卒中是最常见的脑卒中类型,可导致严重的神经功能障碍,但目前缺乏有效的诊断方法和治疗手段。外泌体是一种天然的囊泡,可以通过递送蛋白质、脂质、核酸发挥细胞间通讯的作用。缺血性卒中发生后,外泌体分泌量增加且内容物发生变化,因此可以作为潜在的生物标志物,用以辅助缺血性卒中的诊断和治疗。本文旨在综述外泌体在缺血性卒中中潜在的诊断价值,并探讨外泌体在卒中后的修复作用以及作为药物载体的应用前景,最后我们简要介绍了基于外泌体的临床研究现状。Ischemic stroke(IS)is the most common type of stroke that can lead to severe neurological dysfunction while effective diagnostic and therapeutic methods are currently limited.Exosomes are natural vesicles that can play a key role in intercellular communication by delivering proteins,lipids,and nucleic acids.Notably,IS could cause changes in the level and content of exosome,which can serve as a potential biomarker to assist the diagnosis and treatment of IS.This article reviews the potential diagnostic value of exosomes,discusses their repair effects,and explores the potential application as drug carriers in IS.We also provide a concise summary of the current clinical research status based on exosomes.

关 键 词：缺血性卒中 外泌体 诊断 治疗 药物输送 

分 类 号：R743[医药卫生—神经病学与精神病学]