靶向抑制铁死亡在脑出血后继发性脑损伤治疗中的作用研究进展  

Recent progress of targeting the ferroptosis for the treatment of secondary brain injury after intracerebral hemorrhage

作　　者：孙会艳[1] 李强 王洪权[1] Sun Huiyan;Li Qiang;Wang Hongquan(Chifeng University Health Science Center,Chifeng,Inner Mongolia Autonomous Region 024000,China;不详)

机构地区：[1]赤峰学院医学部,024000 [2]赤峰学院附属医院神经内科

出　　处：《中国脑血管病杂志》2024年第1期59-64,共6页Chinese Journal of Cerebrovascular Diseases

基　　金：内蒙古自然科学基金(2021MS08131、2021LHMS08024)。

摘　　要：脑出血后继发性脑损伤(SBI-ICH)可导致神经元的不可逆损伤。研究表明,细胞铁死亡可以介导脑出血后神经元死亡的病理过程,而抑制铁死亡能够有效地减少SBI-ICH。作者综述了铁死亡参与SBI-ICH的发病机制及药物靶向抑制铁死亡在SBI-ICH防治方面应用的研究进展,以期为脑出血防治方法的探索提供帮助。The secondary brain injury after intracerebral hemorrhage(SBI-ICH)contributes to irreversible damage to neurons.Emerging evidences have shown that ferroptosis is involved in the pathological process of SBI-ICH-related neuronal death.Accumulating studies have suggested that the inhibition of ferroptosis may effectively prevent neuronal damage.The authors systematically summarized the pathological pathways of ferroptosis following ICH and then reviewed the application of ferroptosis inhibitors to mitigate neuron death induced by SBI-ICH,in order to provide help for the exploration of prevention and treatment of cerebral hemorrhage.

关 键 词：脑出血 铁死亡 神经保护 铁死亡抑制剂 继发性脑损伤 综述 

分 类 号：R743.34[医药卫生—神经病学与精神病学]