终末期肝病肌少症及其营养干预研究进展  

Sarcopenia and nutritional intervention in end-stage liver disease

作　　者：李智鹏 朱姝[1] 罗秋敏[1] 许文雄[1] 张烨琼[1] 郑杏容 谢婵[1] 彭亮[1,2] LI Zhipeng;ZHU Shu;LUO Qiumin;XU Wenxiong;ZHANG Yeqiong;ZHENG Xingrong;XIE Chan;PENG Liang(Department of Infectious Diseases,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630,China;Guangdong Provincial Key Laboratory of Liver Disease Research,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院感染性疾病科,广州510630 [2]广东省肝脏病重点实验室,广州510630

出　　处：《西南医科大学学报》2024年第1期15-19,共5页Journal of Southwest Medical University

基　　金：国家自然科学基金(82070611);广东省自然科学基金(2020A1515010317);广东省基础与应用基础研究基金(21202104030000608,2021A1515220029);广州市科技计划项目(202102010204,2023B03J1287);中山大学临床研究项目(2020007,2018009);中山大学科技成果转化项目(82000-18843236);中山大学附属第三医院“五个五计划”(K00006,P02421)。

摘　　要：近几十年,肌少症一直是医学研究的热点。由于营养不良和肝-肌轴中多种代谢介质变化等因素,肌少症常见于终末期肝病患者,与肝硬化失代偿、死亡及移植后不良事件等结局相关。CT检查是评估终末期肝病患者肌肉含量减少的金标准。目前,运动训练及营养干预是肌少症的主要治疗措施。相比于运动训练,营养干预对晚期肝病患者更切实可行。因此,本文对肌少症的定义、机制、诊断以及营养干预进行评述,以期为终末期肝病患者肌少症营养干预提供借鉴和参考。In several decades,Sarcopenia has been a focus of medical disciplines.Due to malnutrition and mediators in the liver-muscle axis,sarcopenia is common in patients of end-stage liver disease and is associated with a wide spectrum of adverse out-comes including hepatic decompensation,death and adverse posttransplant outcomes..CT is considered to be a gold standard for assess-ing loss of muscle mass in patients with end-stage liver disease.Exercise and nutritional intervention prevail as mainstays of treatment.Compared with exercise training,nutrition interventions are targeted and tailored for patients of advanced liver disease.Therefore,this article reviewed the definition,mechanism,diagnosis and nutritional intervention of sarcopenia,in order to provide reference for nutri-tional intervention of sarcopenia in patients with end-stage liver disease.

关 键 词：终末期肝病 肌少症 营养干预 

分 类 号：R575[医药卫生—消化系统]