重视肝再生能力在肝衰竭预后评估中的价值  

The value of liver regeneration ability in prognosis assessment of liver failure should be emphasized

作　　者：吴红 刘林 汤善宏 WU Hong;LIU Lin;TANG Shanhong(Department of Gastroenterology,The General Hospital of Western Theater Command,Chengdu 610083,China)

机构地区：[1]西部战区总医院消化内科,成都610083

出　　处：《西南医科大学学报》2024年第1期25-28,共4页Journal of Southwest Medical University

基　　金：四川省中医药管理局课题(2023MS458)。

摘　　要：肝衰竭患者病情危重,短期死亡率高,预后差,其预后相关因素与模型是国内外研究热点。除肝移植外,肝衰竭患者预后依靠肝脏的再生修复能力,但目前关于肝再生相关指标及模型的关注较少。本课题组近年来报道了血清甲胎蛋白(serum alpha-fetoprotein,AFP)在排除肝癌等其它原因后,可作为肝再生可靠的血清标记物,对肝衰竭患者有重要的良好预后提示作用。本文评述肝再生在重型肝炎尤其是在肝衰竭中的研究现状,以及AFP作为肝再生因子对肝衰竭等重型肝炎患者的预后提示作用,以期提高临床医护人员对肝衰竭患者的预后判断能力,并在此基础上制定合理的诊疗方案,提高对肝衰竭患者的临床诊治能力。Patients with liver failure have severe condition,high short-term mortality and poor prognosis,and the prognostic fac-tors and models are research hotspots at home and abroad.In addition to liver transplantation,the prognosis of patients with liver failure depends on the ability of liver regeneration and repair,but there is little attention on the indicators and models of liver regeneration.In recent years,our research group has reported that serum alpha-fetoprotein(AFP)can be used as a reliable serum marker for liver re-generation after excluding liver cancer and other causes,and has an important prognostic effect on patients with liver failure.This paper summarized the current research status of liver regeneration in severe hepatitis,especially in liver failure,and the prognostic function of AFP as a liver regeneration factor in patients with severe hepatitis such as liver failure,which could improve the ability of clinicians to judge the prognosis of patients with liver failure,and formulate reasonable diagnosis and treatment plans on this basis,and improve the clinical diagnosis and treatment ability of liver failure.

关 键 词：肝再生 肝衰竭 甲胎蛋白 血清标记物 预后提示 

分 类 号：R575.3[医药卫生—消化系统]