HR-HPV阴性的ASC-US患者发生宫颈上皮内病变的影响因素分析  

Analysis of Influencing Factors of Cervical Intraepithelial Lesions in HRHPV-negative ASC-US Patients

作　　者：张锡坚 吴丹 ZHANG Xijian;WU Dan(Department of Laboratory,Nancheng Hospital,Dongguan,Guangdong Province,523071 China)

机构地区：[1]东莞市南城医院检验科,广东东莞523071

出　　处：《系统医学》2023年第22期82-84,92,共4页Systems Medicine

摘　　要：目的 分析高危型人乳头状病毒(high risk human papillomavirus, HR-HPV)阴性的无明确意义的非典型鳞状上皮细胞(atypical squamous cell of undetermined significance, ASC-US)患者发生宫颈上皮内病变的影响因素。方法 选取2021年3月—2023年3月期间东莞市南城医院收治的发生宫颈上皮内病变的60例患者为研究对象(其宫颈液基细胞学检查均为ASC-US、HR-HPV阴性),给予宫颈活检术检查,分析其临床资料。结果 宫颈活检结果显示,高级别鳞状上皮内病变(high-grade squamous intraepithelial lesion, HSIL)及以上患者为7例,低级别鳞状上皮内病变(low-grade squamous intraepithelial lesion, LSIL)及以下患者为53例。单因素分析结果显示,是否绝经在HSIL及以上患者和LSIL及以下患者之间,差异有统计学意义(P<0.05);多因素分析结果显示,绝经是HR-HPV阴性的ASC-US患者发生HSIL及以上病变的保护因素,阴道镜评估结果是HR-HPV阴性的ASC-US患者发生HSIL及以上病变的危险因素(OR=0.105、2.248,P<0.05)。结论 HR-HPV阴性的ASC-US患者中阴道镜评估结果显示HSIL及以上的患者发生HSIL及以上病变风险增加,需要加大患者的关注度,及时开展评估和治疗。Objective To analyze the factors associated with cervical intraepithelial lesions in high risk human papillo-mavirus(HR-HPV)negative and atypical squamous cell of undetermined significance(ASC-US)patients.Methods A total of 60 patients with cervical intraepithelial lesions admitted to Dongguan Nancheng Hospital from March 2021 to March 2023 were selected as the study objects.The cervical fluid-based cytology of the patient was ASC-US and HR-HPV negative.The cervical biopsy was performed and the clinical data of these patients were analyzed.Results There were 7 patients had high-grade squamous intraepithelial lesion(HSIL)and the lesions worse,while 53 patients had low-grade squamous intraepithelial lesions(LSIL)and the lesions better.Univariate acceptance showed that the differ-ence of menopause between the patients had HSIL and the lesions worse and the patients had LSIL and the lesions better was statistically significant(P<0.05).Multivariate analysis showed that menopause was a protective factor for HSIL and the lesions worse in HR-HPV negative and ASC-US patients and colposcopic evaluation results was a risk factor for HSIL and the lesions worse in HR-HPV negative and ASC-US patients(OR=0.10,2.248,P<0.05).Conclu-sion HR-HPV negative and ASC-US patients with colposcopic evaluation results of HSIL and the lesions worse had a higer risk of having HSIL and the lesions worse,which require more attention and timely evaluation and treatment.

关 键 词：液基细胞学检查 高危型人乳头状病毒 未明确意义的不典型鳞状上皮细胞 宫颈上皮肉瘤变 

分 类 号：R737[医药卫生—肿瘤]