Palladium-Catalyzed[4+4]Cycloaddition of Homo-TMM All-Carbon 1,4-Dipole Precursors for Construction of Benzofuro[3,2-b]azocines and Furo[3,2-b]azocines  

作　　者：Ying Chen Meng Zang Weije Wang Yang-zi Liu Xiaoyan Luo Wei-Ping Deng 

机构地区：[1]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China [2]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,College of Chemistry and Materials Science,ZhejiangNormal University,Jinhua,Zhejiang 321004,China

出　　处：《Chinese Journal of Chemistry》2023年第21期2825-2831,共7页中国化学（英文版）

基　　金：We are grateful for financial support from National Key Research and Development Program of China(2021YFA0804900);the NSFC(22171082,21971062);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2022R01007);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism.

摘　　要：We developed a novel Pd-catalyzed[4+4]cycloaddition of(benzo)furan-derived azadienes with homo-TMM all-carbon 1,4-dipoles in situ generated fromα-allyl malonate derivatives,affording an array of benzofuro[3,2-b]azocines and furo[3,2-b]azocines with good to excellent yields(up to 96%)and exclusive regioselectivities.This methodology featured mild reaction conditions and good functional group tolerance.The synthetic utility was demonstrated by a gram-scale reaction.Furthermore,the catalytic asymmetric[4+4]cycloaddition version has also been explored.

关 键 词：PD-CATALYZED [4+4]cycloaddition Homo-TMM 1 4-dipoles Methodology and reactions Medium-ring compounds Regioselectivity 

分 类 号：O62[理学—有机化学]