消毒汤联合人干扰素α2b凝胶治疗宫颈高危型HPV感染临床疗效观察  

Observation of the clinical efficacy of antiseptic decoction combined with human interferonα2b gel for treating patients with cervical high-risk human papillomavirus infection

作　　者：苏婷婷 钟君燕 王美霞 伊欣 陈浩波 SU Tingting;ZHONG Junyan;WANG Meixia;YI Xin;CHEN Haobo(The second Clinical College of Zhejiang Chinese Medicinal University,Hangzhou,Zhejiang Province,310053;Wenzhou Integrated Traditional Chinese and Western Medicine Hospital,Wenzhou,Zhejiang Province;Dalian Medical University,Dalian,Liaoning Province)

机构地区：[1]浙江中医药大学第二临床医学,杭州310053 [2]浙江省温州市中西医结合医院 [3]大连医科大学

出　　处：《中国计划生育学杂志》2024年第1期172-176,共5页Chinese Journal of Family Planning

基　　金：温州市中西医结合学会临床科研基金项目(2021006)。

摘　　要：目的:观察消毒汤联合人干扰素α2b凝胶治疗宫颈高危型人乳头瘤病毒(HR-HPV)感染的临床疗效.方法:选取2020年12月-2022年12月符合纳入标准的90例HR-HPV感染患者为研究对象,根据随机数字表法分为空白组、西药组和联合组各30例.空白组不给予用药,西药组采用人干扰素α2b凝胶单独治疗,联合组采用人干扰素α2b凝胶联合消毒汤治疗,3组均持续治疗3个月经周期.观察三组患者治疗后的HR-HPV疗效和中医证候积分变化情况.结果:治疗后3组中医证候积分总分均较前降低(P<0.05),联合组的中医证候积分改善优于西药组及空白组(P<0.05).治疗后3组HR-HPV疗效和中医证侯积分均具有统计学差异(P<0.05),且联合组均优于西药组及空白组(P<0.05).结论:消毒汤联合人干扰素α2b凝胶治疗HR-HPV感染可有效缓解患者的临床症状,提高HR-HPV的转阴率.Objective:To observe the clinical eficacy of antiseptice decoction combined with human interferon a2b gel for treating patients with cervical high-risk human pillomnavirus(HR-HPV)infection.Methods:90 patients with HRHPV infection who met the inclusion criteria from December 2020 to December 2022 were randomly divided into 30 cases without treatment in group A,30 cases with treatment of antiseptic decoction in group B for 3 menstrual cycles continually and 30 cases with treatment of antiseptic decoction combined with human interferon a2b gel in group C for 3 menstrual cycles continually.The blank group was not given medicine,the western medicine group was treated with human interferon a2b gel alone,and the combined group was treated with human interferon a2b gel combined with antiseptic mixture.All three groups were treated.The curative efect and the changes of TCM syndrome scores of the patients in the three groups after treatment were observed.Results:The TCM syndrome scores of the patients in the three groups after treatment had decreased significantly(P<0.05).The improvement of TCM syndrome score of the patients in group C was significantly better than that of the patients in group B and in group A(P<0.05).The eclinical efficacy and the TCM changes of the patients of the patients after treatment had significant differences among the throe groups(P<0.05).and which of the patients in group C were significantly better than those of the patients in group B and in group A(P<0.05).Conclusion:The antiseptic decoction combined with human interferon a2b gel for treating the patients with cervical HR HPV infection can efectively relieve their clinical symptoms and increase their negative conversion rate of HR-HPV.

关 键 词：宫颈高危型人乳头瘤病毒 人干扰素α2b凝胶 消毒汤 

分 类 号：R737.33[医药卫生—肿瘤]