急性脑梗死患者应用丁苯酞联合依达拉奉治疗的效果探讨  

Discussion on effect of combined use of butylphthalide and edaravone in patients with acute cerebral infarction

作　　者：王斌[1] 沈卫莉 WANG Bin;SHEN Wei-li(Department of Internal Medicine-Neurology,Zaozhuang Taierzhuang District People's Hospital,Zaozhuang 277400,China)

机构地区：[1]枣庄市台儿庄区人民医院神经内科,277400 [2]枣庄市台儿庄区人民医院外二科,277400

出　　处：《中国实用医药》2024年第1期1-5,共5页China Practical Medicine

摘　　要：目的探讨丁苯酞联合依达拉奉治疗急性脑梗死患者的临床效果。方法76例急性脑梗死患者,通过随机数字表法分为观察组和对照组,各38例。对照组予以丁苯酞治疗,观察组应用丁苯酞联合依达拉奉治疗。比较两组治疗效果、神经功能缺损情况、生活自理能力、血清炎症介质水平及生活质量、负面情绪改善情况。结果观察组治疗总有效率94.74%显著高于对照组的78.95%,差异具有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分均低于治疗前,改良Barthel指数(BI指数)均高于治疗前,且观察组NIHSS评分(12.30±1.23)分低于对照组的(24.61±1.80)分,BI指数(81.45±8.27)分高于对照组的(74.39±7.46)分,差异具有统计学意义(P<0.05)。治疗后,观察组社会功能、生理功能、情感职能、生理职能、精神健康、活力、总体健康、躯体疼痛评分分别为(86.22±3.34)、(86.19±4.55)、(89.33±3.23)、(88.11±5.21)、(90.64±1.87)、(83.19±3.23)、(87.43±3.22)、(83.15±2.98)分,均高于对照组的(83.11±2.42)、(80.98±5.21)、(83.21±4.01)、(83.33±4.43)、(84.19±2.76)、(76.34±2.58)、(82.12±2.67)、(77.19±3.04)分,差异具有统计学意义(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且观察组IL-6(3.86±1.03)ng/L、IL-8(0.46±0.05)ng/ml、TNF-α(138.62±26.31)pg/ml均低于对照组的(4.69±1.05)ng/L、(0.51±0.08)ng/ml、(351.62±29.62)pg/ml,差异具有统计学意义(P<0.05)。治疗后,两组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于治疗前,且观察组SAS评分(50.38±2.24)分、SDS评分(52.01±2.24)分均低于对照组的(55.86±3.03)、(56.69±3.02)分,差异具有统计学意义(P<0.05)。结论急性脑梗死应用丁苯酞联合依达拉奉治疗效果显著,能够改善患者神经功能缺损和生活自理能力,降低血清炎症因子水平,提升患者生活质量,值得Objective To explore the clinical effect of combined use of butylphthalide and edaravone in the treatment of patients with acute cerebral infarction.Methods 76 patients with acute cerebral infarction were randomly divided into an observation group and a control group according to random numerical table.The control group was treated with butylphthalide,while the observation group was treated with butylphthalide and edaravone.The treatment effect,neurological function defect,self-care ability,serum inflammatory mediator levels,quality of life,and improvement of negative emotions were compared between the two groups.Results The total effective rate of 94.74%in the observation group was significantly higher than that of 78.95%in the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in both groups was lower than that before treatment in this group,and the modified Barthel index(BI)score was higher than that before treatment in this group;NIHSS score of(12.30±1.23)points in the observation group was lower than that of(24.61±1.80)points in the control group;BI score of(81.45±8.27)points in the observation group was higher than that of(74.39±7.46)points in the control group;the differences were statistically significant(P<0.05).After treatment,the scores of social functioning,physical functioning,role-emotional,role-physical,mental health,vitality,overall health,and bodily pain of patients in the observation group were(86.22±3.34),(86.19±4.55),(89.33±3.23),(88.11±5.21),(90.64±1.87),(83.19±3.23),(87.43±3.22),and(83.15±2.98)points,which were significantly higher than those of(83.11±2.42),(80.98±5.21),(83.21±4.01),(83.33±4.43),(84.19±2.76),(76.34±2.58),(82.12±2.67),and(77.19±3.04)points in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in both groups were lower than those before

关 键 词：急性脑梗死 丁苯酞 依达拉奉 临床效果 炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]