经胸腔镜微创手术治疗原发性纵隔肿瘤的疗效及对患者生活质量的影响探讨  

Efficacy of thoracoscopic minimally invasive surgery on primary mediastinal tumor and its influence on patients'quality of life

作　　者：宋伟[1] 王恩华 SONG Wei;WANG En-hua(Thoracic Surgery Department,Zoucheng People's Hospital,Jining 273500,China)

机构地区：[1]邹城市人民医院胸外科,273500

出　　处：《中国实用医药》2024年第1期46-49,共4页China Practical Medicine

摘　　要：目的探讨原发性纵隔肿瘤患者实施经胸腔镜微创手术治疗的效果及对生活质量的影响。方法选择80例原发性纵隔肿瘤患者,依据随机数字表法分为对照组和研究组,每组患者40例。对照组患者以传统开胸手术实施治疗,研究组患者利用经胸腔镜微创手术治疗。记录并对比两组患者的临床指标(切口长度、手术用时、术中出血量、引流时间、住院时间)、炎症因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-1β(IL-1β)、白介素-6(IL-6)]、生活质量评分以及并发症(切口感染、轻微声嘶、饮水呛咳)发生情况。结果研究组患者的手术用时(130.41±23.52)min、切口长度(3.45±1.14)cm、引流时间(2.26±0.43)d及住院时间(6.55±2.23)d均比对照组的(185.67±27.34)min、(14.53±2.85)cm、(4.52±0.65)d、(9.72±2.36)d短,术中出血量(114.56±13.21)ml比对照组的(159.71±27.35)ml少,差异均具有统计学意义(P<0.05)。治疗后,研究组患者的TNF-α(50.32±5.26)pg/ml、CRP(7.82±0.76)mg/L、IL-1β(49.32±13.63)pg/ml、IL-6(49.32±22.75)pg/ml比对照组的(78.29±5.83)pg/ml、(10.26±1.11)mg/L、(65.43±17.45)pg/ml、(91.41±37.02)pg/ml低,差异均具有统计学意义(P<0.05)。治疗后,研究组患者的社会交往的能力评分(80.81±8.92)分、精神情况评分(81.46±7.92)分、心理情况评分(81.46±6.69)分比对照组的(72.16±8.65)、(73.73±7.01)、(70.67±6.85)分高,差异均具有统计学意义(P<0.05)。治疗后,研究组并发症发生率5.00%低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论原发性纵隔肿瘤患者开展经胸腔镜微创手术进行治疗的临床效果较好,能减少炎症情况的产生,促使患者整体生活质量得到提升,并减少并发症,临床上值得推广使用。Objective To discuss the effect of thoracoscopic minimally invasive surgery on primary mediastinal tumor and its influence on patients'quality of life.Methods 80 patients with primary mediastinal tumor were selected and divided into a control group and a study group according to random numerical table,with 40 patients in each group.The control group was treated with conventional thoracotomy,while the study group was treated with thoracoscopic minimally invasive surgery.Record and comparison were made on clinical indicators(incision length,operative time,intraoperative blood loss,drainage time,length of hospital stay),inflammatory factors[tumor necrosis factor-ɑ(TNF-ɑ),C-reactive protein(CRP),interleukin-1β(IL-1β),interleukin-6(IL-6)],quality of life score,and complications(incision infection,mild hoarseness,coughing due to drinking water)between the two groups.Results The operative time of patients in the study group was(130.41±23.52)min,the incision length was(3.45±1.14)cm,the drainage time was(2.26±0.43)d and the length of hospital stay was(6.55±2.23)d,which were all shorter than those of(185.67±27.34)min,(14.53±2.85)cm,(4.52±0.65)d and(9.72±2.36)d in the control group;and the intraoperative blood loss of(114.56±13.21)ml was less than that of(159.71±27.35)ml in the control group.The difference was statistically significant(P<0.05).After treatment,TNF-ɑin the study group was(50.32±5.26)pg/ml,CRP was(7.82±0.76)mg/L,IL-1βwas(49.32±13.63)pg/ml,and IL-6 was(49.32±22.75)pg/ml,which were all lower than those of(78.29±5.83)pg/ml,(10.26±1.11)mg/L,(65.43±17.45)pg/ml,and(91.41±37.02)pg/ml in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of social communication ability of the study group was(80.81±8.92)points,the score of mental status was(81.46±7.92)points and the score of psychological status was(81.46±6.69)points,which were higher than those of(72.16±8.65),(73.73±7.01)and(70.67±6.85)points of the control group.The difference was statis

关 键 词：经胸腔镜微创手术 原发性纵隔肿瘤 并发症 生活质量 

分 类 号：R734.5[医药卫生—肿瘤]