右美托咪定在心血管手术麻醉中的应用阐述  

Application of dexmedetomidine in anesthesia for cardiovascular surgery

作　　者：田烨晖 费宏亮 TIAN Ye-hui;FEI Hong-liang(Department of Anesthesiology,Beijing Yanhua Hospital,Beijing 102500,China)

机构地区：[1]北京燕化医院麻醉科,102500

出　　处：《中国实用医药》2024年第1期175-177,共3页China Practical Medicine

摘　　要：右美托咪定为α2肾上腺素能受体激动剂,其具有高选择性、镇静镇痛作用显著等特点,在近年临床麻醉中使用频率、使用范围不断扩大,促使临床麻醉质量不断提升。心血管疾病发生率在近年不断上升,心血管手术实施率自然也随之增加,此类手术具有创伤性大、难度与风险性高等特点,麻醉质量对手术安全与患者术后恢复效果等均有直接影响,相关研究发现右美托咪定不仅具有显著镇静、镇痛作用,同时对患者血流动力学稳定性、炎性水平、心肌功能及心律失常、心肌梗死发生率等均具有一定改善效果,从而保障患者安全,避免其因此产生其他不良症状,以此促进手术治疗效果的提高。本文将以此展开研究,分析右美托咪定特性、作用机制及在不同年龄段心血管手术中的具体应用状况等,促使右美托咪定在心血管手术中可发挥最大作用。Dexmedetomidine is anα2 adrenergic receptor agonist with high selectivity and significant sedative and analgesic effects.In recent years,dexmedetomidine has been used in clinical anesthesia with increasing frequency and scope,which promotes the continuous improvement of clinical anesthesia quality.The incidence of cardiovascular diseases has been on the rise in recent years,and the implementation rate of cardiovascular surgery has naturally increased.Such surgery is characterized by high trauma,difficulty and risk,and the quality of anesthesia has a direct impact on surgical safety and postoperative recovery effect of patients.Relevant studies have found that dexmedetomidine not only has significant sedative and analgesic effects,at the same time,it can improve the hemodynamic stability,inflammatory level,myocardial function,arrhythmia,and incidence of myocardial infarction,so as to ensure the safety of patients,avoid other adverse symptoms,and promote the effect of surgical treatment.This paper will conduct a study based on this,and analyze the characteristics,mechanism of action and specific application of dexmedetomidine in cardiovascular surgery at different ages,so as to maximize the role of dexmedetomidine in cardiovascular surgery.

关 键 词：右美托咪定 心血管手术 作用机制 药理学特征 

分 类 号：R614[医药卫生—麻醉学]