简易精神状态量表联合尿神经丝蛋白检测在阿尔茨海默病中的临床价值  

Clinical Value of the Mini-Mental State Examination Combined with Urinary Neurofilament Protein Test in Alzheimer's Disease

作　　者：曾结霞 彭妙寒 龙庆媚 Zeng Jiexia;Peng Miaohan;Long Qingmei(Foshan Jianxiang Nursing Home,,Foshan 528000,Guangdong Province,China;Foshan Jianxiang Orthopedic Injury Hospital,Foshan 528000,Guangdong Province,China)

机构地区：[1]佛山健翔护理院,广东佛山528000 [2]佛山健翔骨伤医院,广东佛山528000

出　　处：《中外医药研究》2023年第22期144-146,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：2021年佛山市卫生健康局医学科研(编号:20210285)。

摘　　要：目的:分析简易精神状态量表(MMSE)联合尿神经丝蛋白(AD7c-NTP)检测在阿尔茨海默病中的应用效果。方法:选取2021年1月—2023年3月佛山健翔护理院收治的阿尔茨海默病患者100例为研究组,选取同期健康体检人员40例为对照组。两组研究对象均进行MMSE评估、检测尿AD7C-NTP水平。比较两组MMSE评分、尿AD7C-NTP水平,比较研究组中不同认知程度患者的MMSE评分、尿AD7C-NTP水平。结果:研究组患者MMSE评分低于对照组,尿AD7C-NTP水平高于对照组,差异有统计学意义(P<0.001)。重度患者MMSE评分低于中度组,尿AD7C-NTP水平高于中度组,差异有统计学意义(P<0.001);中度患者MMSE评分低于轻度组,尿AD7C-NTP水平高于轻度组,差异有统计学意义(P<0.001)。结论:MMSE联合尿AD7C-NTP检测中,尿AD7C-NTP检测水平随阿尔茨海默病认知功能障碍严重程度增加,水平也升高,对于判断患者病情程度具有重要的作用。Objective:To analyze the application effect of the Mini-Mental State Examination(MMSE)combined with urinary neurofilament protein(AD7c-NTP)test in Alzheimer's disease.Methods:One hundred patients with Alzheimer's disease admitted to Foshan Jianxiang Nursing Home from January 2021 to March 2023 were selected as the study group,and forty cases of health checkups in the same period were selected as the control group.Both groups of study subjects underwent MMSE assessment and detection of urinary AD7C-NTP levels.MMSE scores and urinary AD7C-NTP levels were compared between the two groups,and MMSE scores and urinary AD7C-NTP levels were compared between patients with different cognitive levels in the study group.Results:MMSE scores of patients in the study group were lower than those of the control group,and urinary AD7C-NTP levels were higher than those of the control group,and the difference was statistically significant(P<0.001);Severe patients had lower MMSE scores than the moderate group and higher urinary AD7C-NTP levels than the moderate group,with statistically significant differences(P<0.001);The MMSE score of moderate patients was lower than that of the mild group,and the urinary AD7C-NTP level was higher than that of the mild group,and the difference was statistically significant(P<0.001).Conclusion:In MMSE combined with urinary AD7C-NTP test,the level of urinary AD7C-NTP test increased with the severity of cognitive dysfunction in Alzheimer's disease,and the level also increased,which is important for judging the degree of the patient's condition.

关 键 词：简易精神状态量表 尿神经丝蛋白 阿尔茨海默病 

分 类 号：R74[医药卫生—神经病学与精神病学]