地塞米松不同疗程对肉芽肿性乳腺炎患者疗效和预后的影响  

Effect of Different Courses of Dexamethasone on the Efficacy and Prognosis of Patients with Granulomatous Mastitis

作　　者：赖洁敏 邓玉红 Lai Jiemin;Deng Yuhong(Department of Pharmacy,Dongguan Wanjiang Hospital,Dongguan 523000,Guangdong Province,China;Department of Galactophore,Dongguan Wanjiang Hospital,Dongguan 523000,Guangdong Province,China)

机构地区：[1]东莞市万江医院药剂科,广东东莞523000 [2]东莞市万江医院乳腺科,广东东莞523000

出　　处：《中外医药研究》2023年第23期58-60,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:比较不同疗程地塞米松治疗肉芽肿性乳腺炎的临床效果及远期预后。方法:选取2013年1月—2022年6月于东莞市万江医院、东莞市东城医院就诊的肉芽肿性乳腺炎患者90例为研究对象,采用随机数字表法分为单疗程组(n=30)、多疗程组(n=30)、非地塞米松组(n=30)。单疗程组地塞米松片治疗1~7 d,多疗程组地塞米松片治疗8~28 d,非地塞米松组应用第三代头孢菌素治疗5 d。比较三组病灶最大径、疼痛情况、手术治疗率、不良反应,随访12个月记录复发情况。结果:治疗后,三组病灶最大径、视觉模拟评分(VAS)均降低,单疗程组、多疗程组病灶最大径、VAS评分低于非地塞米松组,差异有统计学意义(P<0.05);三组手术治疗率比较,差异无统计学意义(P>0.05);多疗程组药物不良反应总发生率高于单疗程组、非地塞米松组,差异有统计学意义(P<0.05);三组复发率比较,差异无统计学意义(P>0.05)。结论:地塞米松可短期内缓解肉芽肿性乳腺炎患者疼痛症状,但从长期预后来看,多疗程应用地塞米松不会提高疗效和减少疾病复发,反而有较高的不良反应发生风险,因此临床应谨慎选用地塞米松。Objective:To compare the clinical effects and long-term prognosis of different courses of dexamethasone in the treatment of granulomatous mastitis.Methods:Ninety patients with granulomatous mastitis who attended Dongguan Wanjiang Hospital and Dongguan Dongcheng Hospital from January 2013 to June 2022 were selected for the study,and were divided into the single-course group(n=30),the multiple-course group(n=30),and the non-dexamethasone group(n=30)using the randomized numeric table method.The single-course group was treated with dexamethasone tablets for 1-7 d,the multiple-course group was treated with dexamethasone tablets for 8-28 d,and the non-dexamethasone group was treated with third-generation cephalosporins for 5 d.The maximum diameter of the lesion,pain,surgical treatment rate and adverse reactions of the three groups were compared,and the recurrence was recorded at a follow-up of 12 months.Results:After treatment,the maximum diameter of the lesion and the Visual Analog Scale(VAS)decreased in the three groups,and the maximum diameter of the lesion and the VAS score in the singlecourse group and the multiple-course group were lower than in the non-dexamethasone group,and the difference was statistically significant(P<0.05);there was no significant difference in the surgical treatment rate among the three groups(P>0.05);the total incidence of adverse drug reactions in the multiple-course group was higher than in the single-course group and the nondexamethasone group,and the difference was statistically significant(P<0.05);there was no significant difference in recurrence rate among the three groups(P>0.05).Conclusion:Dexamethasone can relieve the pain symptoms of patients with granulomatous mastitis in the short term,but in terms of long-term prognosis,the application of dexamethasone in multiple-course will not improve the efficacy of treatment and reduce the recurrence of the disease,but rather has a higher risk of adverse reactions,so dexamethasone should be used with caution in the clinic.

关 键 词：肉芽肿性乳腺炎 地塞米松 单疗程 多疗程 

分 类 号：R73[医药卫生—肿瘤]