幽门螺杆菌诱导上皮-间质转化在胃癌中的作用机制  

Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori

作　　者：孙振灿 周举坤 许云鹏 王军[2,3] 郑亚 王玉平[2,4] 姬瑞[2,3,4] SUN Zhencan;ZHOU Jukun;XU Yunpeng;WANG Jun;ZHENG Ya;WANG Yuping;JI Rui(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,China;Digestive Endoscopy Center,the First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Province Clinical Research Center for Digestive Diseases,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院消化科,兰州730000 [3]兰州大学第一医院消化内镜中心,兰州730000 [4]兰州大学第一医院甘肃省消化系疾病临床医学研究中心,兰州730000

出　　处：《协和医学杂志》2024年第1期160-165,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：兰州市人才创新创业项目(2019-RC-33);兰州大学医学部定向探索项目(lzuyxcx-2022-184)。

摘　　要：幽门螺杆菌(Helicobacter pylori,Hp)是一种单极、微需氧、多鞭毛、螺旋形的革兰氏阴性菌,可在人胃黏膜上存活并定植。Hp作为与胃癌相关的Ⅰ类致癌物,其对胃黏膜的长期刺激可导致萎缩性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤等多种疾病。研究表明,Hp感染可诱导胃上皮细胞发生上皮-间质转化(epithelial-mesenchymal transition,EMT),而EMT的异常调控则会导致胃癌发生。本文就Hp诱导胃上皮细胞发生EMT致胃癌的相关机制研究展开综述,为胃癌的早期诊断和靶向治疗提供新思路。Helicobacter pylori(Hp) is a unipolar,microaerobic,multiflagellar,spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa.As a classⅠcarcinogen associated with gastric cancer,long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis,peptic ulcer,gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma.It has been reported that Hp can cause epithelial-mesenchymal transition(EMT) in gastric epithelial cells,thereby inducing gastric cancer.We review the mechanism of Hp-induced EMT in gastric epithelial cells,in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.

关 键 词：幽门螺杆菌 上皮-间质转化 胃癌 细胞毒素相关基因A 间充质干细胞 

分 类 号：R735.2[医药卫生—肿瘤] R573[医药卫生—临床医学] R516