南疆部分居民区鼠类中汉坦病毒自然感染状况的初步调查  

Preliminary investigation on natural infection of hantavirus in rodents in some residential areas of southern Xinjiang

作　　者：王启果[1] 古丽阿依·包开西[1] 罗勇军 阿布力克木·阿布都热西提[1] 王信惠[1] 安允萍[2] 高宏进 吐尔德古丽·别拉沙尔 骆骋 马瑞杰 王希江[1] WANG Qi-guo;Guliayi BAOKAIXI;LUO Yong-jun;Abulikemu ABUDUREXITI;WANG Xin-hui;AN Yun-ping;GAO Hong-jin;Tuerdeguli BIELASHAER;LUO Cheng;MA Rui-jie;WANG Xi-jiang(Department of Emergency and Plague Control,the Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830002,China;不详)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心应急处置与鼠疫防治所,乌鲁木齐830002 [2]新疆喀什地区疾病预防控制中心,新疆喀什844000 [3]新疆克孜勒苏柯尔克孜自治州疾病预防控制中心,新疆阿图什845350 [4]新疆和田地区疾病预防控制中心,新疆和田848000 [5]新疆巴音郭楞蒙古自治州疾病预防控制中心,新疆库尔勒841000 [6]新疆阿克苏地区疾病预防控制中心,新疆阿克苏843000

出　　处：《疾病预防控制通报》2023年第6期1-3,20,共4页Bulletin of Disease Control & Prevention(China)

基　　金：新疆维吾尔自治区自然科学基金资助项目(2021D01C126);新疆维吾尔自治区疾病预防控制中心青年科研基金资助项目(202001)。

摘　　要：目的初步了解南疆部分居民区鼠类中汉坦病毒的自然感染状况。方法2023年春季和夏季,分别在喀什地区、克孜勒苏柯尔克孜自治州(克州)、和田地区、阿克苏地区、巴音郭楞蒙古自治州(巴州)27个县(市)居民区捕获鼠类,取其肾脏,采用流行性出血热Ⅰ型(汉坦病毒)、Ⅱ型(汉城病毒)双重荧光PCR法检测核酸。结果春季喀什地区5个县(市)(喀什市、疏附县、巴楚县、莎车县、叶城县)均监测到流行性出血热Ⅱ型(汉城病毒)分布,鼠类总携带率为22.4%(38/170),携带率在11.1%~37.0%,不同县(市)鼠类携带率之间差异有统计学意义(χ^(2)=9.822,P=0.044);夏季27个县(市)中,监测到汉城病毒分布12个、分布率44.4%,共捕鼠598只、总携带率11.9%(71/598),携带率在0.0%~52.4%,其中喀什地区、克州、和田地区的携带率分别为19.1%(56/293)、28.3%(13/46)、1.5%(2/131),阿克苏和巴州未监测到汉坦病毒携带,鼠类携带率喀什(χ^(2)=23.710,P<0.001)与克州(P<0.001,Fisher’s exact test)均明显高于和田。喀什地区5个县(市)居民区鼠类汉坦病毒携带率春季(22.4%)与夏季(23.1%)差异无统计学意义(χ^(2)=0.025,P=0.874)。结论流行性出血热Ⅱ型(汉城病毒)在南疆的分布较广,不同地区鼠类病毒携带率有差异,部分县(市)携带率较高,流行性出血热疫情暴发的风险不容忽视。Objective To investigate the natural infection status of hantavirus in rodents in some residential areas of southern Xinjiang.Methods In spring and summer of 2023,the rodents and the kidney samples were collected in 27 counties(cities)around Kashi prefecture,Kizilsu Kirgiz autonomous prefecture(Kezhou for short),Hetian prefecture,Aksu prefecture and Bayingoleng Mongolian autonomous prefecture(Bazhou for short),and the nucleic acid of epidemic hemorrhagic fever type I(hantavirus)and type II(Seoul virus)were detected by double fluorescent PCR.Results In spring,the Seoul virus was monitored among 5 counties/cities(Kashi city,Shufu county,Bachu county,Shache county and Yecheng county)in Kashi prefecture,with the total virus carrying rate of 22.4%(38/170)in rodents,ranged from 11.1%to 37.0%.There was statistical difference(χ^(2)=9.822,P=0.044)in the virus carrying rates among different counties.In summer,the Seoul virus was detected in 12 out of 27 counties/cities,with distribution rate of 44.4%.There were 598 rodents captured,with the total carrying rate was 11.9%(71/598),ranged from 0.0%to 52.4%.The carrying rate in Kashi,Kezhou and Hetian was 19.1%(56/293),28.3%(13/46)and 1.5%(2/131),respectively,and no hantavirus was detected in Akesu and Bazhou.The carrying rates of hantavirus in Kashi prefecture(χ^(2)=23.710,P<0.001)and Kezhou(Fisher's exact test,P<0.001)were significantly higher than that in Hetian.There was no statistical difference(χ^(2)=0.025,P=0.874)between the hantavirus carrying rates in spring(22.4%)and summer(23.1%).Conclusions The epidemic hemorrhagic fever of type II(Seoul virus)widely distribute in southern Xinjiang,with different hantavirus carrying rates in different areas.The carrying rates are high in part of counties(cities).The risk of outbreak of epidemic hemorrhagic fever cannot be ignored.

关 键 词：流行性出血热 汉坦病毒 鼠类 携带率 

分 类 号：R512.8[医药卫生—内科学]