不同浓度阿托品对中国儿童近视控制效果的Meta分析  

A Meta-analysis on the effects of different concentrations of atropine on myopia in Chinese children

作　　者：李阳 李秀霞 冯鲜妮[1] 张丽梅[1] 郭康乐 LI Yang;LI Xiuxia;FENG Xianni;ZHANG Limei;GUO Kangle(The Jiuquan City People’s Hospital,Jiuquan 735000,Gansu Province,China;School of Public Health,Lanzhou University,Lanzhou 730000,Gansu Province,China;Gansu Provincial People’s Hospital,Lanzhou 730000,Gansu Province,China)

机构地区：[1]酒泉市人民医院,甘肃省酒泉市735000 [2]兰州大学公共卫生学院,甘肃省兰州市730000 [3]甘肃省人民医院,甘肃省兰州市730000

出　　处：《眼科新进展》2024年第2期133-138,共6页Recent Advances in Ophthalmology

基　　金：甘肃省酒泉市民生科技计划A类项目(编号:2023MA1011)。

摘　　要：目的系统评价不同浓度阿托品对中国儿童近视的控制效果。方法计算机检索PubMed、Embase、The Cochrane Library、Web of Science、CBM、WanFang Data、VIP和CNKI数据库,搜集关于阿托品控制儿童近视的研究,检索时限均从建库至2023年4月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。结果共纳入32项研究,包括7种不同浓度阿托品对比安慰剂的结果。Meta分析结果显示,与安慰剂相比,0.1 g•L^(-1)阿托品对等效球镜度变化有显著的影响[MD=0.39,95%CI(0.26,0.52),P<0.05],能够显著抑制眼轴长度的增加[MD=-0.18,95%CI(-0.24,-0.12),P<0.05]。其他浓度中,0.2 g•L^(-1)、0.5 g•L^(-1)及10 g•L^(-1)阿托品均对近视的控制均有较好的效果。结论现有证据显示,与安慰剂相比,0.1 g•L^(-1)、0.2 g•L^(-1)、0.5 g•L^(-1)及10 g•L^(-1)阿托品对儿童近视等效球镜度及眼轴长度的控制均有较好的效果,其中0.1 g•L^(-1)阿托品可能具有最好的效果。Objective To systematically evaluate the control effects of different concentrations of atropine on myopia in Chinese children.Methods PubMed,Embase,The Cochrane Library,Web of Science,CBM,WanFang Data,VIP and CNKI databases were retrieved to collect the studies on children’s myopia control by atropine from the establishment of the database to April 2023.After the literature screening,data extraction and bias risk valuation were carried out by 2 researchers,a Meta-analysis was performed via RevMan 5.4 software.Results A total of 32 studies were included,comparing the effects of 7 different concentrations of atropine and placebo.The Meta-analysis showed that compared with placebo,0.1 g•L^(-1) atropine had a significant impact on the change of spherical equivalent[MD=0.39,95%CI(0.26,0.52),P<0.05],and significantly suppressed the axial length increment[MD=-0.18,95%CI(-0.24,-0.12),P<0.05].Among other concentrations,0.2 g•L^(-1),0.5 g•L^(-1) and 10 g•L^(-1) atropine had sound effects on myopia control.Conclusion Existing evidence shows that compared to placebo,atropine at concentrations of 0.1 g•L^(-1),0.2 g•L^(-1),0.5 g•L^(-1) and 10 g•L^(-1) has better effects on controlling the spherical equivalent and axial length of children with myopia.Among them,atropine at the concentration of 0.1 g•L^(-1) may have the best effect.

关 键 词：阿托品 中国儿童 近视控制 META分析 

分 类 号：R778.1[医药卫生—眼科]