Alterations of Audiovisual Integration in Alzheimer’s Disease  

作　　者：Yufei Liu Zhibin Wang Tao Wei Shaojiong Zhou Yunsi Yin Yingxin Mi Xiaoduo Liu Yi Tang 

机构地区：[1]Department of Neurology and Innovation Center for Neurological Disorders,Xuanwu Hospital,Capital Medical University,National Center for Neurological Disorders,Beijing,100053,China

出　　处：《Neuroscience Bulletin》2023年第12期1859-1872,共14页神经科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC3602600);National Natural Science Foundation of China(82220108009,81970996);STI2030-Major Projects(2021ZD0201801).

摘　　要：Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer’s disease(AD).In this review,we evaluated the altered audiovisual integrative behavioral symptoms in AD.We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD,including the imbalance between energy demand and supply,activity-dependent degeneration,disrupted brain networks,and cognitive resource overloading.Then,based on the clinical characteristics including electrophysiological and imaging data related to audiovisual integration,we emphasized the value of audiovisual integration alterations as potential biomarkers for the early diagnosis and progression of AD.We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients.Moreover,investigation into audiovisual integration alterations in AD also provided new insights and comprehension about sensory information processes.

关 键 词：Audiovisual integration-Aging Alzheimer's disease COGNITION Sensory information process 

分 类 号：R749.16[医药卫生—神经病学与精神病学]