龋病与系统性疾病相关性的研究进展  

Research progress in associations between dental caries and systemic diseases

作　　者：王欣欢 徐子淇 边专[1] 孟柳燕[1] Wang Xinhuan;Xu Ziqi;Bian Zhuan;Meng Liuyan(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医(学)院、口颌系统重建与再生全国重点实验室、口腔生物医学教育部重点实验室、口腔医学湖北省重点实验室,武汉430079

出　　处：《中华口腔医学杂志》2024年第1期99-104,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82071107,81870761,82170944,81970923)。

摘　　要：龋病是在以细菌为主的多种因素影响下,发生于牙体硬组织的一种慢性进行性破坏性疾病。近年来,越来越多研究关注龋病与系统性疾病之间的相关性。本文将对PubMed和Web of Science中2003—2022年发表的评估龋病与系统性疾病关联的文献进行综述,主要涵盖心血管疾病、代谢性疾病、呼吸系统疾病、风湿免疫系统疾病、神经系统疾病、胃肠道疾病、肾脏疾病、皮肤病、缺铁性贫血和肿瘤等10类疾病。本文将阐述它们与龋病之间的关系和潜在作用机制,以期为口腔和其他专科医师提供更好的疾病预防、诊断和治疗策略。Dental caries is a bacteria-mediated,multifactorial,chronic progressive disease that results in the phasic demineralization and remineralization of dental hard tissues.In recent years,amounts of studies have focused on the association between dental caries and systemic diseases.This paper reviews the researches about associations between caries and systemic diseases.An electronic search was conducted in PubMed and Web of Science for articles published from 2003 to 2022 in the English language.Studies were included in the following ten categories of systemic diseases:cardiovascular diseases,metabolic disorders,respiratory diseases,autoimmune rheumatic diseases,neurologic diseases,gastrointestinal diseases,kidney diseases,skin diseases,iron deficiency anaemia and tumors.This review discusses the relationship between dental caries and systemic diseases,as well as the potentially involved mechanisms,providing new ideas for disease prevention,diagnosis,and treatment strategies for dentists and other clinicians.

关 键 词：龋齿 链球菌 龋齿 链球菌 变异 系统性疾病 牙体硬组织 口腔微生物 

分 类 号：R781.1[医药卫生—口腔医学]