帕金森综合征患者非运动症状发生的影响因素及其对盐酸普拉克索治疗预后的预测价值分析  

Analysis of factors influencing the occurrence of non-motor symptoms in patients with Parkinson′s syndrome and their predictive value for the prognosis of treatment with pramipexole hydrochloride

作　　者：巩忠[1] 许莉[1] 王海鹏[1] 刘洁[1] 王超凡[1] 董文辉[2] Gong Zhong;Xu Li;Wang Haipeng(Department of Medical Neurology,Beijing Aerospace General Hospital,Beijing 100076,China)

机构地区：[1]北京航天总医院神经内科,100076 [2]北京航天总医院健康管理中心,100076

出　　处：《中华保健医学杂志》2023年第5期522-525,共4页Chinese Journal of Health Care and Medicine

基　　金：北京航天总医院创新基金项目(2020-612)。

摘　　要：目的探究帕金森综合征(PS)患者非运动症状(NMS)发生的影响因素及其对盐酸普拉克索治疗预后的预测价值。方法选取2020年5月~2022年5月在北京航天总医院使用盐酸普拉克索进行治疗的PS患者104例,将依据是否有NMS现象,分为NMS组(n=84)与无NMS组(n=20),并比较两组年龄、性别、病程、Hoehn-Yahr(H-Y)病情分级、临床类型等方面差异。通过单因素和多因素logistic回归模型分析NMS发生的影响因素。根据PS患者接受盐酸普拉克索治疗后NMS的预后分为显效组(n=67)和非显效组(n=17)。采用单因素和多因素logistic回归模型分析PS患者NMS经盐酸普拉克索治疗预后的影响因素。结果两组患者的病程、疾病程度、临床类型差异均有统计学意义(P<0.05)。logistic多因素回归分析显示,病程、H-Y病情分级、临床类型是PS患者预后的独立危险因素(P<0.05)。PS患者NMS经盐酸普拉克索治疗显效67例,占比79.76%。单因素分析结果显示,PS患者的年龄、病程、H-Y病情分级、临床类型与盐酸普拉克索治疗PS患者NMS明显相关(P<0.05)。logistic多因素回归分析显示,病程、H-Y病情分级、临床类型是PS患者NMS经盐酸普拉克索治疗预后结局的危险因素(P<0.05)。ROC结果显示,临床类型、H-Y病情分级、病程对预测普拉克索治疗PS患者NMS预后的曲线下面积(AUC)分别为0.644、0.682、0.635,对应灵敏度分别为64.2%、77.6%、38.8%,特异性分别为64.7%、58.8%、88.2%。三者联合诊断的AUC为0.932,灵敏度和特异度分别为83.6%和94.3%。结论PS患者的病程、H-Y病情分级、临床类型是PS患者发生NMS的相关影响因素,同时,三者在普拉克索治疗PS患者NMS预后中差异较大,三者联合对普拉克索治疗PS患者NMS预后的预测效能更好,可在临床应用。Objective To investigate the factors influencing the occurrence of non-motor symptoms(NMS)in patients with Parkinson′s syndrome(PS)and its predictive value analysis on the prognosis of pramipexole hydrochloride treatment.Methods 104 patients with PS treated with pramipexole hydrochloride in our hospital from May 2019 to May 2022 were selected.They were divided into the NMS group(n=84)and the non-NMS group(n=20)based on the presence of NMS.The general data of the two groups were collected,and differences in age,gender,disease duration,H-Y disease severity,and clinical type were compared.Univariate and multivariate logistic regression models were used to analyze the influencing factors of NMS occurrence.PS patients were divided into a significant group(n=67)and a non-significant group(n=17)according to the prognostic outcome of NMS after treatment with pramipexole hydrochloride.The single factor and multi-factor Logistic regression models were used to analyze the influencing factors on the outcome of pramipexole hydrochloride treatment in PS patients with NMS.Results Compared with the non-NMS group,the factors affecting the course of disease,disease degree and clinical type of patients in the NMS group were significantly different(P<0.05).Logistic multivariate regression analysis showed that disease course,H-Y disease grade and clinical type were independent risk factors for the prognosis of PS patients(P<0.05).67 PS patients were treated with pramexol hydrochloride for NMS,accounting for 79.76%.Univariate analysis showed that the age,disease course,H-Y disease grade and clinical type of PS patients were significantly correlated with pramexol hydrochloride treatment of PS patients′NMS(P<0.05).Logistic regression analysis showed that age,course of disease,H-Y disease grade and clinical type were risk factors for the prognosis of PS patients treated with pramexol hydrochloride(P<0.05).The ROC result showed that the area under the curve(AUC)of clinical type,H-Y disease classification,and disease duration for predi

关 键 词：帕金森综合征 盐酸普拉克索 非运动症状 影响因素 

分 类 号：R74[医药卫生—神经病学与精神病学]