miR-601与ESM-1在早期胃癌内镜黏膜下剥离术后复发预测中的价值  

Value of miR-601 and ESM-1 in predicting the recurrence of patients with early gastric cancer after endoscopic submucosal dissection

作　　者：袁殿宝[1] 丁新 高会斌[1] 赵文月[1] 陈文婷[1] 彭涛[1] Yuan Dianbao;Ding Xin;Gao Huibin(Department of Endoscopy,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院内镜中心,张家口075000

出　　处：《中华保健医学杂志》2023年第5期541-544,共4页Chinese Journal of Health Care and Medicine

基　　金：河北省2020年度医学科学研究课题(20200536);张家口市重点研发计划项目(k2020177)。

摘　　要：目的分析miR-601与内皮细胞特异性分子-1(ESM-1)在早期胃癌患者内镜黏膜下剥离术(ESD)后复发预测中的价值。方法选取2017年6月~2020年6月于河北北方学院附属第一医院行ESD治疗的早期胃癌患者288例;同期行胃黏膜活检,病理结果为良性病变的50例患者为对照组。检测胃黏膜miR-601、ESM-1 mRNA的表达量,分析其与临床病理特征的关系。随访胃癌患者术后复发情况,并采用Cox回归进行风险因素分析。结果早期胃癌组患者组织中miR-601、ESM-1 mRNA表达较对照组明显更高,差异有统计学意义(P<0.05);不同性别、年龄、肿瘤最大径、内镜下分型的早期胃癌患者胃黏膜miR-601、ESM-1 mRNA表达量差异无统计学意义(P>0.05)。随着T分期、浸润深度的增加,miR-601、ESM-1 mRNA表达量增加,组间差异有统计学意义(P<0.05);不同分化程度的ESM-1表达差异有统计学意义(P<0.05);复发者胃黏膜组织中miR-601、ESM-1 mRNA表达较未复发者明显更高,差异有统计学意义(P<0.05)。多因素Cox回归分析结果显示,浸润深度、高表达的miR-601及ESM-1 mRNA是影响期胃癌患者术后复发的独立危险因素。结论早期胃癌患者病灶组织中miR-601、ESM-1的表达与其临床病理特征具有一定关系,且是此类患者ESD术后复发的危险因素,可能成为术后复发的预测指标。Objective To analyze the value of miR-601 and endothelial cell-specific molecule-1(ESM-1)in predicting recurrence after endoscopic submucosal dissection(ESD)in patients with early gastric cancer.Methods 288 patients with early gastric cancer who were treated with ESD in our hospital from June 2017 to June 2020 were selected as the study subjects,and 50 patients with benign lesions were selected as the control group.The expression of miR-601 and ESM-1 mRNA in gastric mucosa of the two groups was detected,and their relationship with clinicopathological characteristics was analyzed.Follow up the postoperative recurrence,and use Cox regression to analyze the risk factors.Results The expression of miR-601 and ESM-1 mRNA in patients with early gastric cancer was significantly higher than that in the control group(P<0.05).There was no significant difference in the expression of miR-601 and ESM-1 mRNA in gastric mucosa between the groups of different sex,age,maximum diameter of tumor,endoscopic classification and early gastric cancer(P>0.05).With the increase of T stage and depth of invasion,the expression of miR-601 and ESM-1 mRNA increased,and the difference between groups was statistically significant(P<0.05).The expression of ESM-1 with different degrees of differentiation was statistically significant(P<0.05).The expression of miR-601 and ESM-1 mRNA in gastric mucosa of recurrent patients was significantly higher than that of non-recurrent patients(P<0.05).Multivariate Cox regression analysis showed that the depth of invasion,high expression of miR-601 and ESM-1 mRNA were independent risk factors for postoperative recurrence in patients with stage gastric cancer.Conclusion The expression of mir-601 and ESM-1 in the lesions of patients with early gastric cancer has a certain relationship with their clinicopathological characteristics,and is a risk factor for recurrence after ESD in such patients,which may become a predictor of postoperative recurrence.

关 键 词：早期胃癌 内镜黏膜下剥离术 miR-601 内皮细胞特异性分子-1 

分 类 号：R735[医药卫生—肿瘤]