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作 者:秦雨萌 沙杰[1] Yu-Meng Qin;Jie Sha(Jingjiang People’s Hospital,Taizhou 214500,Jiangsu Province,China)
出 处:《世界华人消化杂志》2023年第24期1001-1006,共6页World Chinese Journal of Digestology
基 金:江苏省中西医结合老年病防治重点实验室资助项目,No.202223.
摘 要:近年来,肠道微生物(gut microbiota,GM)与胰腺癌(pancreatic cancer,PC)的相关性引发了广泛的关注.研究表明,PC患者的口腔、肠道及胰腺内微生物群区别于健康人群,呈现出不同特征.在此基础上,应用特征性的GM及代谢产物作为PC早期诊断、预后评估的生物标志物,具有很大的研究潜力.以GM为靶点的肠道微生态疗法,如益生菌、粪菌移植等,可能通过重塑肿瘤微环境影响对化疗、免疫治疗的应答效果,从而改善预后.本文对GM参与PC发生发展、早期诊断、预后评估、治疗等方面的最新研究进行简要综述.In recent years,the association between the gut microbiota(GM)and pancreatic cancer(PC)has attracted extensive attention.Studies have shown that the oral,intestinal,and pancreatic microbiota of PC patients is different from that of healthy people,showing different characteristics.On this basis,the application of characteristic GM and its metabolites as biomarkers for early diagnosis and prognosis evaluation of PC holds great potential.Intestinal microecological therapy targeting the GM,such as probiotics and fecal microbiota transplantation,may affect the response to chemotherapy and immunotherapy by remodeling the tumor microenvironment,to improve the prognosis.In this paper,we review the role of the GM in PC development,early diagnosis,prognosis assessment,and treatment.
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