浅析细胞自噬在溃疡性结肠炎发病机制中的作用  

Role of autophagy in pathogenesis of ulcerative colitis

作　　者：时艺榕 郝微微 张尔馨 王珠环 李乐 Yi-Rong Shi;Wei-Wei Hao;Er-Xin Zhang;Zhu-Huan Wang;Le Li(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China)

机构地区：[1]上海中医药大学附属曙光医院,上海市200120

出　　处：《世界华人消化杂志》2023年第24期1022-1028,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金,No.81874450和81403362;上海市中医优势病种培育建设项目,No.ZY(2018-20200-ZYBZ-03);上海市中医诊疗模式创新试点建设项目,No.ZY(2018-20200-FWTX-6028).

摘　　要：溃疡性结肠炎是病变累及结直肠黏膜的一种慢性特发性炎性疾病,病情特点是反复发作,主要临床表现为腹痛、腹泻及黏液脓血便等.目前对溃疡性结肠炎的发病机制尚未完全明了,多数学者普遍认为其发病受遗传易感性、环境因素、免疫系统紊乱、微生物组和肠道微菌群失调等因素的影响.近年来,细胞自噬的概念逐渐受到科学界的关注,越来越多的学者在自噬理论的基础上开始研究溃疡性结肠炎的发病机制.本篇综述将从细胞自噬入手浅析其在溃疡性结肠炎发病机制的作用.Ulcerative colitis is a chronic idiopathic inflammatory disease involving the colorectal mucosa.It is characterized by recurrent attacks,such as abdominal pain,diarrhea,mucus,and purulent stool.At present,the pathogenesis of ulcerative colitis is not fully understood.Most scholars generally believe that the pathogenesis of ulcerative colitis is affected by genetic susceptibility,environmental factors,immune system disorders,microflora and intestinal microflora disorders,and other factors.In recent years,the concept of autophagy has gradually attracted the attention of the scientific community,and more and more scholars have begun to study the pathogenesis of ulcerative colitis on the basis of autophagy theory.This review will give an overview of cellular autophagy and discuss its role in the pathogenesis of ulcerative colitis.

关 键 词：溃疡性结肠炎 细胞自噬 发病机制 

分 类 号：R574.62[医药卫生—消化系统]