艾司奥美拉唑联合大剂量阿莫西林治疗幽门螺杆菌感染的疗效观察  

Observation on the efficacy of esomeprazole combined with high-dose amoxicillin the treatment of Helicobacter pylori infection

作　　者：张敏 ZHANG Min(Cao County People's Hospital,Heze 274400,China)

机构地区：[1]曹县人民医院,274400

出　　处：《中国现代药物应用》2024年第1期19-22,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 观察幽门螺杆菌感染患者应用艾司奥美拉唑联合大剂量阿莫西林治疗的临床效果。方法 60例幽门螺杆菌感染患者作为观察对象,经随机数字表法分为观察组及对照组,每组30例。观察组应用艾司奥美拉唑联合大剂量阿莫西林治疗,对照组应用常规四联疗法治疗。比较两组患者的幽门螺杆菌感染根除率,治疗效果,治疗满意度,不良反应发生情况。结果 观察组患者的幽门螺杆菌感染总根除率为96.67%(29/30),高于对照组的80.00%(24/30),差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率为96.67%(29/30),高于对照组的80.00%(24/30),差异具有统计学意义(P<0.05)。观察组患者的治疗满意度为93.33%(28/30),高于对照组的73.33%(22/30),差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为10.00%(3/30),与对照组的20.00%(6/30)比较,差异无统计学意义(P>0.05)。结论 将艾司奥美拉唑联合大剂量阿莫西林治疗方案应用于幽门螺杆菌感染患者中,对于提高幽门螺杆菌根除率,促进患者康复,改善患者预后效果显著,且治疗安全性较高,推荐参考使用。Objective To observe the clinical effect of esomeprazole combined with high-dose amoxicillin for patients with Helicobacter pylori infection.Methods 60 patients with Helicobacter pylori infection were studied and randomly divided into an observation group and a control group using a random number table method,with 30 cases in each group.The observation group was treated with esomeprazole and high-dose amoxicillin,and the control group was treated with conventional quadruple therapy.The eradication rate of Helicobacter pylori infection,effectiveness of treatment,satisfaction with treatment,and occurrence of adverse reactions were compared between the two groups.Results The total eradication rate of Helicobacter pylori infection in the observation group was 96.67%(29/30),which was higher than 80.00%(24/30)in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment of 96.67%(29/30)in the observation group was higher than 80.00%(24/30)in the control group,and the difference was statistically significant(P<0.05).The treatment satisfaction in the observation group was 96.67%(29/30),which was higher than 80.00%(24/30)in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 10.00%(3/30),which had no statistically significant difference compared to 20.00%(6/30)in the control group(P>0.05).Conclusion The application of esomeprazole combined with high-dose amoxicillin for patients with Helicobacter pylori infection has a significant effect on improving the eradication rate of Helicobacter pylori,promoting patient recovery,and improving patient prognosis.Moreover,the treatment safety is high,and it is recommended for reference.

关 键 词：幽门螺杆菌感染 艾司奥美拉唑 大剂量阿莫西林 四联疗法 疗效 

分 类 号：R573[医药卫生—消化系统]