基于谐波分析法观察抑郁症患者脑网络形态学改变  

Harmonic waves analysis for observing morphological brain network changes in depressive disorder patients

作　　者：徐凯 郭志明 曾亚伟 郑冬 吴艳坤 李科 XU Kai;GUO Zhiming;ZENG Yawei;ZHENG Dong;WU Yankun;LI Ke(Department of Radiology,Strategic Support Force Medical Center,Beijing 100101,China;Department of Clinical Psychopharmacology,Peking University Sixth Hospital,Peking University Institute of Mental Health,Beijing 100191,China;Department of Medical&Research,Strategic Support Force Medical Center,Beijing 100101,China)

机构地区：[1]战略支援部队特色医学中心放射诊断科,北京100101 [2]北京大学第六医院北京大学精神卫生研究所精神药理研究室,北京100191 [3]战略支援部队特色医学中心医研部,北京100101

出　　处：《中国医学影像技术》2024年第1期22-26,共5页Chinese Journal of Medical Imaging Technology

基　　金：首都卫生发展科研专项(2022-1-4111)。

摘　　要：目的评估基于谐波分析法观察抑郁症(DD)患者脑网络形态学改变的可行性。方法对55例DD患者(DD组)和46名正常对照者(NC组)采集全脑3D高分辨T1WI,利用FreeSurfer 5.3.0工具构建脑网络6种形态学特征,包括脑区顶点数、表面积、灰质体积、平均皮层厚度、高斯曲率及折叠指数,以拉普拉斯矩阵特征分解获得公共谐波;比较组间不同形态学特征所在谐波能量及脑区灰质体积。结果组间不同形态学特征总谐波能量差异均无统计学意义(P均>0.05)。组间特定谐波能量差异有统计学意义(P均<0.05),主要包括脑区顶点数谐波能量差异为第2、6、15、44、57谐波,表面积谐波能量差异为第2、6、16、57谐波,灰质体积谐波能量差异为第2、12、13、15、57谐波,平均皮层厚度谐波能量差异为第2、19、35、36、44谐波,高斯曲率谐波能量差异为第34、40、54、57谐波,以及折叠指数谐波能量差异为第5、16、21、57谐波。DD组左脑区颞横皮质区域灰质体积显著大于NC组(t=2.900,P=0.004)。结论谐波分析法可用于观察DD患者脑网络形态学改变。Objective To explore the feasibility of harmonic waves analysis for observing morphological brain network changes in patients with depressive disorder(DD).Methods Whole brain 3D high resolution T1WI of 55 DD patients(DD group)and 46 normal controls(NC group)were acquired.Six kinds of morphological features brain network were constructed with FreeSurfer tool,including the number of brain region vertices,surface area,gray matter volume,average cortical thickness,Gaussian curvature and fold index.Laplace operator was applied to obtain common harmonic wave.The harmonic power of different morphological features and the gray matter volume in different brain regions were compared between groups.Results No significant difference of total harmonic energy was found between groups.The specific harmonic wave energies were significantly different between groups,including the number of brain region vertices corresponding to the 2nd,6th,15th,44th and 57th harmonic waves,surface area corresponding to the 2nd,6th,16th and 57th harmonic waves,gray matter volume corresponding to the 2nd,12th,13th,15th and 57th harmonic waves,average cortical thickness corresponding to the 2nd,19th,35th,36th and 44th harmonic waves,Gaussian curvature corresponding to the 34th,40th,54th and 57th harmonic waves,as well as fold index corresponding to the 5th,16th,21st and 57th harmonic waves.Gray matter volumes of transverse temporal gyrus in left hemisphere in DD group were significantly larger than that in NC group(t=2.900,P=0.004).Conclusion Harmonic waves analysis was feasible for observing morphological brain network changes in DD patients.

关 键 词：抑郁症 磁共振成像 脉搏波分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]