^(18)F-FDOPA PET/CT评估放射化学治疗用于高级别脑胶质瘤效果  

^(18)F-FDOPA PET/CT for evaluating efficacy of radiotherapy combined with chemotherapy for advanced glioma

作　　者：马国津 李佳晶 崔金利[1] 林秀玉[1] MA Guojin;LI Jiajing;CUI Jinli;LIN Xiuyu(Department of Medical Imaging,Affiliated Hospital of Changchun University of Traditional Chinese Medicine,Changchun 130021,China;Department of Medical Imaging,Jilin Institute of Population Life Science and Technology,Changchun 130021,China)

机构地区：[1]长春中医药大学附属医院医学影像科,吉林长春130021 [2]吉林省人口生命科学技术研究院医学影像科,吉林长春130021

出　　处：《中国医学影像技术》2024年第1期27-31,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察以^(18)F-L-6-氟-3,4-二羟基苯丙氨酸(^(18)F-FDOPA)PET/CT评估放射及化学治疗(放疗及化疗)用于高级别脑胶质瘤效果的价值。方法回顾性分析84例接受精准放疗及同步化疗的高级别脑胶质瘤患者资料,根据疗效将其分为有效组(完全缓解+部分缓解+疾病稳定,n=60)及无效组(疾病进展,n=24)。比较组间及组内治疗前后肿瘤^(18)F-FDOPA PET/CT代谢参数,包括肿瘤代谢体积(MTV)、最大标准摄取值(SUV_(max))及平均标准摄取值(SUV_(mean));以Spearman相关性分析观察代谢参数与放化疗效果的相关性。结果治疗后有效组MTV、SUV_(max)及SUV_(mean)均低于无效组(P均<0.05)。有效组治疗前、后代谢参数差异有统计学意义(P均<0.05)。高级别脑胶质瘤MTV、SUV_(max)、SUV_(mean)与放化疗效果呈负相关(r=-0.63、-0.52、-0.50,P<0.001、P=0.007、P=0.010)。结论^(18)F-FDOPA PET/CT有助于评估放化疗用于高级别脑胶质瘤效果。Objective To observe the value of^(18)F-fluoro-dihydroxy-phenylalanine(^(18)F-FDOPA)PET/CT for evaluating the efficacy of radiochemotherapy for advanced glioma.Methods Data of 84 patients with advanced glioma who received precision radiotherapy combined with synchronous chemotherapy were retrospectively analyzed.The patients were divided into effective group(complete remission+partial remission+stable disease,n=60)and ineffective group(progressive disease,n=24)according to the efficacy of radiochemotherapy.^(18)F-FDOPA PET/CT metabolic parameters of tumors,including tumor metabolic tumor volume(MTV),_(max)imum standard uptake value(SUV_(max))and_(mean)standard uptake value(SUV_(mean))were compared between groups,also before and after radiochemotherapy within groups.Spearman correlation analysis was used to observe the correlations of metabolic parameters and the efficacy of radiochemotherapy.Results After radiochemotherapy,MTV,SUV_(max)and SUV_(mean)of tumors in effective group were lower than those of tumors in ineffective group(all P<0.05).Significant differences of metabolic parameters were found before and after radiochemotherapy in effective group(all P<0.05).MTV,SUV_(max)and SUV_(mean)of advanced glioma were negatively correlated with the efficacy of radiochemotherapy(r=-0.63,-0.52,-0.50,P<0.001,P=0.007,P=0.010).Conclusion^(18)F-FDOPA PET/CT was helpful for evaluating the efficacy of radiochemotherapy for advanced glioma.

关 键 词：胶质瘤 放射治疗 药物治疗 正电子发射断层显像 

分 类 号：R739.41[医药卫生—肿瘤] R817.4[医药卫生—临床医学]