小GTP酶Rab22a在疾病中的作用及机制  

The role and mechanism of small GTPases Rab22a in diseases

作　　者：孙可馨 王泽佳 秦芳凝 王金萍 王亮[2] 李庆昌[2] 邱雪杉[2] 王恩华[2] SUN Ke-xin;WANG Ze-jia;QIN Fang-ning;WANG Jin-ping;WANG Liang;LI Qing-chang;QIU Xue-shan;WANG En-hua(China Medical University-The Queen's University of Belfast Joint College,China Medical University,Shenyang 110122,China;Department of Pathology,College of Basic Medical Science,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学中英联合学院,辽宁沈阳110122 [2]中国医科大学基础医学院病理学教研室,辽宁沈阳110122

出　　处：《解剖科学进展》2023年第5期552-554,共3页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81874214);辽宁省科技厅社发攻关及产业化资助项目(2017225010);2020年中国医科大学大学生创新创业训练计划(x202010159054)。

摘　　要：Rab22a是Rab家族的一个小GTP酶,介导细胞免疫系统,很大程度上介导病原体感染的胞内运输,与感染性疾病的发生发展关联密切。Rab22a是一种致癌基因,首次被发现在大多数人类肝癌中,随后发现在多种不同的恶性肿瘤中均会发生上调,在促进肿瘤发生发展过程中的作用可能通过调控microRNA调控轴及低氧微环境中囊泡的转运实现,但具体作用机制尚不明确。此外,Rab22a与非肿瘤性疾病也具有一定的相关性,Rab22a蛋白的低表达可能会引起与阿尔兹海默病发病机制相关的淀粉样蛋白累积,在系统性红斑狼疮,关节炎及动脉粥样硬化的发病机制中表现出相关性。Rab22a is a small GTPase of Rab family,mediates the cellular immune system and intracellular transport of pathogen infection to a large extent,which is closely related to the occurrence and development of infectious diseases.Rab22a is an oncogene,first discovered in most human liver cancers,and then found to be up-regulated in a variety of different malignant tumors.It promotes the occurrence and development of tumors via regulating the microRNA regulatory axis and the transport of vesicles in the hypoxic microenvironment,but the specific mechanism of action is still unclear.In addition,Rab22a is also related to non-neoplastic diseases.The low expression of Rab22a protein may cause amyloid accumulation involved in the pathogenesis of Alzheimer's disease.It is also involved in the pathogenesis of systemic lupus erythematosus,arthritis and atherosclerosis.

关 键 词：非肿瘤性疾病 系统性红斑狼疮 阿尔兹海默病 致癌基因 感染性疾病 动脉粥样硬化 淀粉样蛋白 病原体感染 

分 类 号：R361.1[医药卫生—病理学]