线粒体应激与细胞蛋白稳态和适应  

Mitochondrial stress and cell protein homeostasis and adaptation

作　　者：李倩竹 王梦伊 张世武 舒凤 张伟华[1] LI Qian-zhu;WANG Meng-yi;ZHANG Shi-wu;SHU Feng;ZHANG Wei-hua(Department of Pathophysiology,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学病理生理学教研室,黑龙江哈尔滨150080

出　　处：《解剖科学进展》2023年第5期555-557,560,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81970317)。

摘　　要：线粒体是细胞内氧化磷酸化(OXPHOS)和合成三磷酸腺苷(ATP)的主要场所,在维持细胞存活,细胞死亡和细胞代谢稳态方面发挥重要作用。当线粒体功能受到干扰时,许多重要的生命过程会受到损害,导致许多疾病的发生。因此,维持线粒体完整性和稳态对于确保细胞和有机体生存至关重要。在应激作用下,线粒体通过诱导一系列的细胞反应来减少应激带来的不良后果,包括线粒体未折叠蛋白反应(UPR^(mt))向细胞核传递受到应激的线粒体信号。关闭蛋白质翻译,以及其他细胞质蛋白网络的稳定对于恢复线粒体功能也非常重要,如线粒体前体过度积累应激(mPOS)。Mitochondria are the main site of oxidative phosphorylation and synthesis of ATP in cells,play an important role in maintaining cell survival,cell death,and cell metabolic homeostasis.While mitochondrial function is disrupted,many important life processes are impaired,leading to many diseases.Therefore,maintaining mitochondrial integrity and homeostasis is crucial for ensuring the survival of cells and organisms.Mitochondrial stress can induce a series of cellular adaptation to reduce the adverse effects of stress,including mitochondrial unfolded protein response(UPR^(mt))which transmits stressed mitochondrial signals to the nucleus,shutting down protein translation.The stability of some cytoplasmic protein networks is also important for restoring mitochondrial function,such as mitochondrial precursor over-accumulation stress(mPOS).

关 键 词：线粒体功能 应激作用 细胞反应 细胞蛋白 细胞死亡 细胞存活 蛋白质翻译 线粒体应激 

分 类 号：R363[医药卫生—病理学]