超小型钌纳米粒子抗氧化作用研究  

Research on Antioxidant Effect of Ultrasmall Ruthenium Nanoparticles

作　　者：张立夏 朱旭峰 马晶晶 ZHANG Li-xia;ZHU Xv-feng;MA Jing-jing(Pharmacy Department of Suzhou Dushu Lake Hospital,Suzhou Jiangsu 215125,China;Guangdong Medical University,Zhanjiang Guangdong 524002,China)

机构地区：[1]苏州市独墅湖医院药学部,江苏苏州215125 [2]广东医科大学,广东湛江524002

出　　处：《当代化工》2023年第12期2883-2888,共6页Contemporary Chemical Industry

基　　金：广东省医学科学技术研究基金,可调控宿主保护性免疫的钌配合物功能化纳米酶及其抗耐药细菌感染的研究(项目编号:A2023217)。

摘　　要：近年来,具有活性氧清除作用的无机纳米粒子在疾病治疗领域引起了广泛的关注。然而,超小型钌纳米粒子(Ru NPs)与活性氧(ROS)的相互作用并没有被系统的研究。基于此,在体外及细胞水平研究了RuNPs的抗氧化作用。结果表明:RuNPs具有类过氧化物歧化酶和类过氧化氢酶活性,可以催化过氧化氢分解,并有效清除超氧阴离子和羟基自由基。此外,Ru NPs具有较好的生物安全性,并能够减轻小胶质细胞的氧化应激反应,为基础研究和临床应用提供了科学依据。Research on inorganic nanoparticles able to scavenge reactive oxygen species has undergone a tremendous growth recently.However,the interaction between ultrasmall ruthenium nanoparticles(Ru NPs)and reactive oxygen(ROS)have not been systematically explored.In this article,the antioxidant effects of Ru NPs in vitro and in cells were explored.The results showed that Ru NPs had superoxide dismutase-like and catalase-like activities,could catalyze the decomposition of hydrogen peroxide,and effectively scavenge superoxide anions and hydroxyl radicals.Meanwhile,Ru NPs exhibited favourable biosecurity and antioxidant effects in microglial cells,provideing scientific basis for basic research and clinical applications.

关 键 词：钌纳米粒子 活性氧 抗氧化活性 氧化应激 

分 类 号：TQ426.97[化学工程] R318.08[医药卫生—生物医学工程]