长链非编码核糖核酸心肌梗死转录本在视网膜缺血性疾病中的研究进展  

Research progress of LncRNA myocardial infarction transcripts in retinal ischemic diseases

作　　者：王志斌[1] 周小瑞 底煜[2] Wang Zhibin;Zhou Xiaorui;Di Yu(The Second Clinical Medical College,China Medical University,Shenyang 110004,China;Department of Ophthalmology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学第二临床学院,沈阳110004 [2]中国医科大学附属盛京医院眼科,沈阳110004

出　　处：《中华眼科医学杂志（电子版）》2023年第5期296-300,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家自然科学基金项目(81600747);辽宁省教育厅基金项目(QNZR2020010);沈阳市科技厅项目(21-173-9-52)。

摘　　要：视网膜缺血性疾病包括视网膜动脉阻塞、视网膜静脉阻塞、糖尿病视网膜病变及早产儿视网膜病变等常见疾病,其发病机制主要与动脉粥样硬化和视网膜新生血管有关,此类疾病可造成患者视力的严重丧失,是一类复杂且具有挑战性的疾病。当前,长链非编码核糖核酸(LncRNA)是生物学研究的热门领域之一。近年来,许多学者开展了心肌梗死转录本(MIAT)在视网膜缺血性疾病中作用的研究。本文中笔者就LncRNA MIAT在组织细胞增殖、凋亡、氧化应激、神经变性、免疫、炎症反应、焦亡、铁死亡、自噬及上皮间质转化等多种病理过程中的作用机制进行综述。Retinal ischemic diseases include retinal artery occlusion,retinal vein occlusion,diabetes retinopathy,retinopathy of prematurity and other common diseases.Its pathogenesis is mainly related to atherosclerosis and retinal neovascularization.Such diseases can cause severe loss of vision in patients,and are a group of complex and challenging diseases.Currently,long chain non coding ribonucleic acid(LncRNA)is one of the hot research areas in biology.In recent years,the role of myocardial infarction transcripts(MIATs)in retinal ischemic diseases has paid more attention for many scholars.In this paper,the mechanisms of LncRNA MIAT in various pathological processes such as tissue cell proliferation,apoptosis,oxidative stress,neurodegeneration,immunity,inflammatory response,pyroptosis,ferroptosis,autophagy,and epithelial mesenchymal transition were reviewed.

关 键 词：视网膜缺血性疾病 长链非编码核糖核酸 心肌梗死转录本 视网膜新生血管 

分 类 号：R774.1[医药卫生—眼科]