中药材经磷化铝熏蒸后残留磷化氢的降解规律研究  

Study on the Degradation of Aluminum Phosphide Residues in Chinese Medicinal Materials

作　　者：戚鹏飞 王月玲 徐雪梅 邱国玉 李运 邵长春 Qi Pengfei;Wang Yueling;Xu Xuemei;Qiu Guoyu;Li Yun;Shao Changchun(Lanzhou Institute for Food and Drug Testing,State Key Laboratory for Pesticide and Veterinary Drug Residues in Food,Lanzhou 730050,China;Gansu Pharmaceutical Group Science and Technology Innovation Research Institute Co.,Ltd.,Lanzhou 730050,China)

机构地区：[1]兰州市食品药品检验检测研究院/国家市场监管食品中农药兽药残留监控重点实验室,甘肃兰州730050 [2]甘肃药业集团科技创新研究院有限公司,甘肃兰州730050

出　　处：《亚太传统医药》2024年第1期72-75,共4页Asia-Pacific Traditional Medicine

基　　金：甘肃省药品监督管理局药品科研项目(2020GSMPA033);甘肃省药品监督管理局药品科研项目(2022GSMPA0069);2022年度甘肃中医药产业创新联合体项目(22ZD6FA021);兰州市科学技术局兰州市科技计划项目(2022-2-45);甘肃省药品监督管理局药品科研项目(2021GSMPA006)。

摘　　要：目的:研究经磷化铝熏蒸后中药材中磷化氢残留水平的变化规律。方法:选取党参、黄芪、当归等易生虫的十种中药材经过模拟实验建立阳性样本,通过建立磷化铝残留的测定方法,对制备样本进行磷化铝残留水平监测。结果:不同品种的中药材样品经磷化铝熏蒸后残留水平有明显差异,对于含有色素的款冬花药材,外观颜色发生明显变化。同时发现,阳性样品在自然通风条件下,磷化氢残留降解速度较快,在48h内降幅可达约50%以上,8天后残留量明显减少,12天后部分样品残留量低于检出限。结论:不同基质的中药材样品经磷化铝熏蒸后,残留水平有明显差异,且磷化氢残留随贮存时间延长降解速度加快。Objective:To study the changes of residual levels in Chinese medicinal materials after aluminum phosphide fumigation.Methods:10 kinds of Chinese medicinal materials such as Codonopsis,Astragalus and Angelica were selected and positive samples were established by simulation experiment.The aluminum phosphide residue level was monitored by the established method for determination of aluminum phosphide residue.Results:It was found that there were obvious differences in the residual levels of different varieties of Chinese medicinal materials after fumigation with aluminum phosphide.At the same time,it was found that the phosphine residue degradation rate of positive samples was faster under natural ventilation conditions,and the reduction rate could reach more than 50%within 48 hours,the residual amount was significantly reduced after 8 days,and the residual amount of some samples was lower than the detection limit after 12 days.Conclusion:There are obvious differences in the residual levels of Chinese medicinal materials in different substrates,and the residual phosphine degrades faster with storage time.

关 键 词：中药材 中药饮片 磷化氢残留量 贮藏时间 降解规律 

分 类 号：R282[医药卫生—中药学]