脑卒中患者血清ox-LDL、ANGPTL8、IL-18变化及其与神经功能缺损程度的关系  

Changes of serum ox-LDL,ANGPTL8 and IL-18 in patients with stroke and their relationship with degree of neurological impairment

作　　者：邓希兰 董瑞 王志琪 DENG Xilan;DONG Rui;WANG Zhiqi(Department of Neurology,Yuncheng Central Hospital,Yuncheng,Shanxi,China,044000;Medical Department,Yuncheng Central Hospital,Yuncheng,Shanxi,China,044000)

机构地区：[1]运城市中心医院神经内科,山西运城044000 [2]运城市中心医院医务科,山西运城044000

出　　处：《分子诊断与治疗杂志》2023年第12期2233-2236,2241,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山西省科技攻关项目(20220113014-8)。

摘　　要：目的分析脑卒中患者血清氧化型低密度脂蛋白(ox-LDL)、人血管生成素样蛋白8(ANGPTL8)和白介素18(IL-18)的变化及其与患者神经功能缺损程度的关系。方法选取于2020年1月-2022年12月运城市中心医院接收的106例脑卒中患者作为实验组,使用中国脑卒中患者临床神经功能缺损程度评分量表(CSS)评估患者的神经功能缺损程度,并分为轻度组和中重度组;使用改良Rankin量表(mRS)评估患者预后状况,并分为预后良好组和预后不良组;另随机选取40名健康成年人作为对照组,对实验组和对照组、轻度组和中重度组、预后良好组和预后不良组的血清ox-LDL、ANGPTL8和IL-18水平进行组间比较,使用Pearson直线相关分析血清ox-LDL、ANGPTL8和IL-18与CSS评分的关系,采用受试者工作曲线(ROC)分析血清ox-LDL、ANGPTL8和IL-18水平对脑卒中预后的评估价值。结果实验组血清ox-LDL、ANGPTL8和IL-18水平均高于对照组,差异有统计学意义(P<0.05),中重度组血清ox-LDL、ANGPTL8和IL-18水平均高于轻度组,差异有统计学意义(P<0.05),预后不良组血清ox-LDL、ANGPTL8和IL-18水平均高于预后良好组,差异有统计学意义(P<0.05);脑卒中患者血清ox-LDL、ANGPTL8和IL-18水平与神经功能缺损程度呈正相关(P<0.05);三者联合评估患者预后预测的曲线下面积(AUC)为0.944,ox-LDL、ANGPTL8和IL-18单独评估的AUC为0.849、0.838和0.897,三者联合优于单独评估(P<0.05)。结论脑卒中患者伴血清ox-LDL、ANGPTL8和IL-18水平升高,三指标与神经功能缺损程度呈正相关,三者联合对患者预后预测效能最高,未来有可能成为检测及判断患者预后状况的血清学指标。Objective To analyze the changes of serum oxidized low-density lipoprotein(ox-LDL),human angiopoietin like-8(ANGPTL8)and interleukin-18(IL-18)in patients with stroke and their association with the degree of neurological impairment.Methods 106 patients with stroke admitted to Yuncheng Central Hospital from January 2020 to December 2022 were selected as the experimental group.Chinese scale of clinical neurological deficit of stroke patients(CSS)was used to evaluate the degree of neurological impairment,and the patients were divided into the mild group and the moderate-to-severe group.Modified Rankin Scale(mRS)was applied to evaluate the prognosis status of patients,and the patients were classified into the good prognosis group and the poor prognosis group.In addition,40 healthy adults were randomly selected as the control group,and the levels of serum ox-LDL,ANGPTL8 and IL-18 were compared between the experimental group and the control group.Pearson linear correlation analysis was adopted to analyze the relationship between serum ox-LDL,ANGPTL8 and IL-18 and CSS score.The predicted value of serum ox-LDL,ANGPTL8 and IL-18 for stroke prognosis was analyzed by the receiver operating curve(ROC).Results The levels of serum ox-LDL,ANGPTL8 and IL-18 in the experimental group were higher than those in the control group(P<0.05),and the above levels in the moderate-to-severe group were higher than those in the mild group(P<0.05).Serum ox-LDL,ANGPTL8 and IL-18 levels in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Serum ox-LDL,ANGPTL8 and IL-18 levels were positively correlated with degree of neurological impairment in patients with stroke.When the cut-off of serum ox-LDL in stroke patients was higher than 68.45μg/dL,the sensitivity and specificity of predicting prognosis were 0.795 and 0.881 respectively.When the cut-off of serum ANGPTL8 was higher than 1247.83 pg/mL,the predictive sensitivity and specificity were 0.821 and 0.731 respectively.The sensitivity and specificity of serum IL

关 键 词：脑卒中 氧化型低密度脂蛋白 人血管生成素样蛋白8 白介素18 神经功能缺损程度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]