氯吡格雷联合阿司匹林对急性脑梗死IL-18、IL-33、NT-pro BNP的影响  

Effect of Clopidogrel Combined with Aspirin on IL-18,IL-33 and NT-proBNP in Acute Cerebral Infarction

作　　者：王勇[1] 黄春[2] WANG Yong;HUANG Chun(Department of Emergency,Pingxiang People's Hospital,Pingxiang 337000,China;不详)

机构地区：[1]萍乡市人民医院急诊科,江西萍乡337000 [2]萍乡市人民医院神经内科,江西萍乡337000

出　　处：《中国医学创新》2024年第3期73-76,共4页Medical Innovation of China

摘　　要：目的:分析氯吡格雷联合阿司匹林对急性脑梗死患者血清白细胞介素(IL)-18、IL-33及N末端B型利钠肽原(NT-proBNP)水平及疗效的影响。方法:选取萍乡市人民医院2020年7月—2021年8月收治的急性脑梗死患者72例,以随机数字表法分组,对照组(n=36)在常规治疗基础上使用氯吡格雷治疗,试验组(n=36)在对照组基础上使用阿司匹林治疗,两组均连续服药4周,比较两组炎症因子、NT-proBNP水平,并比较临床疗效及用药不良反应。结果:两组治疗7 d后IL-6、IL-18、IL-33、NT-pro BNP水平均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。试验组临床总有效率为97.22%,高于对照组的77.78%,差异有统计学意义(P<0.05)。试验组总用药不良反应发生率为11.11%,与对照组的8.33%比较,差异无统计学意义(P>0.05)。结论:氯吡格雷联合阿司匹林治疗急性脑梗死,可更好地发挥药效,提高临床效果,降低IL-6、IL-18、IL-33、NT-pro BNP水平,安全有效。Objective:The effects of Clopidogrel combined with Aspirin on serum interleukin-18,IL-33,and N-terminal pro-B-type natriuretic peptide(NT-proBNP) level and efficacy in patients with acute cerebral infarction.Method:Seventy-two patients with acute cerebral infarction admitted to Pingxiang People's Hospital from July 2020 to August 2021 were selected and divided two groups by random number table method.The control group(n=36) was treated with Clopidogrel on the basis of conventional treatment,and the experimental group(n=36)was treated with Aspirin on the basis of the control group.Both groups took the drug continuously for 4 weeks.The levels of inflammatory factors and NT-proBNP were compared between the two groups.The clinical efficacy and adverse drug reactions were compared.Result:The levels of IL-6,IL-18,IL-33 and NT-proBNP in two groups after 7 d of treatment were lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the experimental group was 97.22%,which was higher than 77.78% of the control group,the difference was statistically significant(P<0.05).There was no statistical significance in the incidence of adverse drug reactions in the experimental group(11.11%) and the control group(8.33%)(P>0.05).Conclusion:Clopidogrel combined with Aspirin in the treatment of acute cerebral infarction can better exert its efficacy,improve clinical efficacy,and reduce the levels of IL-6,IL-18,IL-33 and NT-proBNP,which is safe and effective.

关 键 词：氯吡格雷 阿司匹林 急性脑梗死 白细胞介素-18 白细胞介素-33 N末端B型利钠肽原 

分 类 号：R743.33[医药卫生—神经病学与精神病学]