术后血清MMIF、IL-6及PTH水平与甲状腺乳头状癌术后甲状旁腺功能减退的相关性  

Correlation between postoperative serum MMIF,IL-6 and PTH levels and postoperative hypoparathyroidism after papillary thyroid cancer surgery

作　　者：梅长利 李学文 那将超[1] 何亮[1] MEI Changli;LI Xuewen;NA Jiangchao;HE Liang(Department of General Surgery,Pinggu District Hospital,Beijing,China,101200)

机构地区：[1]北京市平谷区医院普外科,北京101200

出　　处：《分子诊断与治疗杂志》2024年第1期170-173,共4页Journal of Molecular Diagnostics and Therapy

基　　金：平谷区医院院内科研课题项目(Pgyy2018-31)。

摘　　要：目的分析术后血清巨噬细胞移动抑制因子(MMIF)、白介素-6(IL-6)及甲状旁腺激素(PTH)水平与甲状腺乳头状癌术后甲状旁腺功能减退的相关性。方法选取2020年6月至2022年4月于北京市平谷区医院确诊为甲状腺乳头状癌并采用甲状腺全切以及颈中央区淋巴结清扫手术患者134例为研究对象。统计患者术后甲状旁腺功能减退发生情况;分析影响患者甲状旁腺功能减退的单因素,并采用多元Logistic回归分析影响甲状旁腺功能减退的危险因素,采用Pearson系数分析术后血清MMIF、IL-6、PTH与甲状旁腺功能减退的相关性。结果134例患者术后甲状旁腺功能正常者112例(83.58%)、甲状旁腺功能减退者22例(16.42%);两组年龄、性别、肿瘤直径等指标比较,差异无统计学意义(P>0.05);两组肿瘤位置、中央区淋巴结清扫位置及数量、合并桥本甲状腺炎以及术后血清MMIF、IL-6、PTH水平比较,差异有统计学意义(P<0.05);多元Logistic回归分析显示:肿瘤位于后背膜、合并患有桥本甲状腺炎以及术后血清MMIF≥2 ng/mL、IL-6>10.0 pg/L、PTH≥15 pg/mL是影响甲状旁腺功能减退的危险因素(P<0.05);Pearson相关性分析可知:术后血清MMIF、IL-6、PTH水平与甲状旁腺功能减退呈正相关(P<0.05)。结论临床可通过检测术后血清MMIF水平、IL-6、PTH水平用以预测甲状腺乳头状癌术后甲状旁腺功能是否出现减退,为治疗提供可靠的依据。Objective To analyze the correlation between serum levels of macrophage movement inhibitory factor(MMIF),interleukin-6(IL-6)and parathyroid hormone(PTH)levels with hypoparathyroidism after surgery for papillary thyroid cancer.Methods 134 patients diagnosed with papillary thyroid carcinoma in our hospital and underwent total thyroidectomy and central cervical lymph node dissection from June 2020 to April 2022 were selected as the study objects.The incidence of postoperative hypoparathyroidism was analyzed.Single factors affecting patients with hypoparathyroidism were analyzed,and multiple Logistic regression was used to analyze the risk factors affecting hypoparathyroidism.Pearson correlation coefficient was used to analyze the correlation between serum MMIF,IL-6,PTH after surgery and hypoparathyroidism.Results Among the 134 patients,112(83.58%)had normal parathyroid function,and 22(16.42%)had hypoparathyroid function after surgery.There was no significant difference in age,sex and tumor diameter between the two groups(P>0.05).There were significant differences in tumor location,central lymph node dissection location and number,combined Hashimoto thyroiditis and postoperative serum MMIF,IL-6 and PTH levels between the two groups(P<0.05).Multiple Logistic regression analysis showedthat the tumor was in the dorsal membrane,combined with Hashimoto thyroiditis combined with postoperative serum MMIF≥2 ng/mL,IL-6>10.0 pg/L,PTH≥15 pg/mL were the risk factors affecting hypoparathyroidism(P<0.05).According to Pearson correlation analysis showed that serum MMIF,IL-6 and PTH levels were positively correlated with hypoparathyroidism(P<0.05).Conclusion The level of serum MMIF,IL-6 and PTH can be used to predict whether the parathyroid function is decreased after the operation of papillary thyroid cancer,which provides a reliable basis for clinical treatment.

关 键 词：MMIF IL-6 PTH 甲状腺乳头状癌 甲状旁腺功能减退 

分 类 号：R736.1[医药卫生—肿瘤]